PMID- 27605566
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20231112
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Print)
IS  - 1099-8004 (Linking)
VI  - 19
IP  - 2
DP  - 2017 Mar
TI  - Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With 
      Heart Failure.
PG  - 153-161
LID - 10.1177/1099800416665197 [doi]
AB  - AIMS: To describe correlations and agreement between salivary and serum B-type 
      natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and 
      IL-10 and determine which biomarkers predict worse functional class in patients 
      with heart failure (HF). METHODS: Serum and saliva were collected from 75 
      hospitalized patients with HF (57 +/- 12 years, 43% female, New York Heart 
      Association [NYHA] Classes I [4%], II [43%], and III [53%]). Oral inflammation 
      was rated as good, fair, or poor. Spearman's rho and Bland-Altman were used to 
      determine correlations and agreement of the salivary and serum forms of each 
      biomarker. Logistic regressions were used to determine which biomarkers predicted 
      worse NYHA functional class, controlling for depression, body mass index, 
      smoking, and oral inflammation. RESULTS: Median biomarker concentrations were as 
      follows: BNP (serum 361 pg/ml, saliva 9 pg/ml), CRP (serum 13 ng/ml, saliva 25.6 
      ng/ml), IL-6 (serum 19.3 pg/ml, saliva 10.5 pg/ml), and IL-10 (serum 64.1 pg/ml, 
      saliva 4.7 pg/ml). There was a moderate-to-strong correlation for serum-salivary 
      CRP, weak correlation for serum-salivary IL-6, and no correlations for 
      serum-salivary BNP and IL-10. The Bland-Altman test showed good salivary-serum 
      agreement for all biomarkers, but as serum concentrations rose, salivary measures 
      underestimated serum levels. Visible oral inflammation was the only predictor of 
      worse NYHA class.
FAU - Dekker, Rebecca L
AU  - Dekker RL
AD  - 1 University of Kentucky College of Nursing, Lexington, KY, USA.
FAU - Lennie, Terry A
AU  - Lennie TA
AD  - 1 University of Kentucky College of Nursing, Lexington, KY, USA.
FAU - Moser, Debra K
AU  - Moser DK
AD  - 1 University of Kentucky College of Nursing, Lexington, KY, USA.
FAU - Miller, Craig S
AU  - Miller CS
AD  - 2 University of Kentucky College of Dentistry, Lexington, KY, USA.
FAU - Ebersole, Jeffrey L
AU  - Ebersole JL
AD  - 2 University of Kentucky College of Dentistry, Lexington, KY, USA.
FAU - Chung, Misook L
AU  - Chung ML
AD  - 1 University of Kentucky College of Nursing, Lexington, KY, USA.
FAU - Campbell, Charles L
AU  - Campbell CL
AD  - 3 University of Tennessee/Erlanger Health Systems in Chattanooga Division of 
      Cardiology, Chattanooga, TN, USA.
FAU - Bailey, Alison
AU  - Bailey A
AD  - 3 University of Tennessee/Erlanger Health Systems in Chattanooga Division of 
      Cardiology, Chattanooga, TN, USA.
FAU - Tovar, Elizabeth G
AU  - Tovar EG
AD  - 1 University of Kentucky College of Nursing, Lexington, KY, USA.
LA  - eng
GR  - K23 NR013480/NR/NINR NIH HHS/United States
GR  - P20 NR010679/NR/NINR NIH HHS/United States
GR  - P30 GM110788/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20160920
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Salivary Proteins and Peptides)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*analysis
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Inflammation/*chemically induced
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Kentucky
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Saliva/*chemistry
MH  - Salivary Proteins and Peptides/analysis
PMC - PMC5942485
OTO - NOTNLM
OT  - B-type natriuretic peptide
OT  - cytokines
OT  - inflammatory biomarkers
OT  - periodontal disease
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2016/09/09 06:00
MHDA- 2017/06/07 06:00
PMCR- 2018/03/01
CRDT- 2016/09/09 06:00
PHST- 2016/09/09 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
PHST- 2016/09/09 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 1099800416665197 [pii]
AID - 10.1177_1099800416665197 [pii]
AID - 10.1177/1099800416665197 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2017 Mar;19(2):153-161. doi: 10.1177/1099800416665197. Epub 2016 
      Sep 20.