PMID- 27605942
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160908
LR  - 20200929
IS  - 1671-5411 (Print)
IS  - 1671-5411 (Linking)
VI  - 13
IP  - 7
DP  - 2016 Jul
TI  - Plasma brain natriuretic peptide level in older outpatients with heart failure is 
      associated with physical frailty, especially with the slowness domain.
PG  - 608-14
LID - 10.11909/j.issn.1671-5411.2016.07.014 [doi]
AB  - OBJECTIVE: To determine the association between plasma brain natriuretic peptide 
      (BNP) level in patients with heart failure (HF) and physical frailty as well as 
      with each domain of physical frailty. METHODS: Two hundred and six outpatients of 
      cardiovascular medicine aged 60 years and older who had been hospitalized for HF 
      or had been given a prescription medication for HF were included. Physical 
      frailty was assessed using the following five domains: slowness, weakness, 
      exhaustion, low activity, and shrinking, according to the Cardiovascular Health 
      Study. Patients were divided into nonfrailty and frailty groups according to 
      frailty scores. Plasma BNP level was measured. The 6-min walk test was performed 
      to measure endurance. RESULTS: Plasma BNP was significantly different between the 
      two groups (frailty group: 158.0 +/- 214.7 pg/mL, nonfrailty group: 65.2 +/- 88.0 
      pg/mL, P < 0.01). Multivariate logistic regression analysis revealed 
      log-transformed plasma BNP (Log BNP) was significantly associated with physical 
      frailty (OR: 1.68, 95% CI: 1.11-2.56), and Log BNP was significantly associated 
      with the slowness domain (walking speed < 1.0 m/s) of physical frailty (OR: 1.75, 
      95% CI: 1.15-2.67). Additionally, Log BNP was negatively correlated to the 
      6-minute walk distance (6MWD) (rho = -0.37, P < 0.01), while 6MWD was positively 
      correlated to walking speed (rho = 0.66, P < 0.01). CONCLUSIONS: Plasma BNP level 
      was related to physical frailty, especially in the slowness domain. Endurance may 
      intervene in the associations between plasma BNP level and walking speed.
FAU - Nishiguchi, Shu
AU  - Nishiguchi S
AD  - Department of Physical Therapy, School of Health Sciences, Tokyo University of 
      Technology, Tokyo, Japan.
FAU - Nozaki, Yuma
AU  - Nozaki Y
AD  - Department of Physical Therapy, Human Health Sciences, Graduate School of 
      Medicine, Kyoto University, Kyoto, Japan.
FAU - Yamaji, Masayuki
AU  - Yamaji M
AD  - Department of Cardiovascular Medicine, Koto Memorial Hospital, Shiga, Japan.
FAU - Oya, Kanako
AU  - Oya K
AD  - Department of Rehabilitation Unit, Koto Memorial Hospital, Shiga, Japan.
FAU - Hikita, Yuki
AU  - Hikita Y
AD  - Department of Rehabilitation Unit, Koto Memorial Hospital, Shiga, Japan.
FAU - Aoyama, Tomoki
AU  - Aoyama T
AD  - Department of Physical Therapy, Human Health Sciences, Graduate School of 
      Medicine, Kyoto University, Kyoto, Japan.
FAU - Mabuchi, Hiroshi
AU  - Mabuchi H
AD  - Department of Cardiovascular Medicine, Koto Memorial Hospital, Shiga, Japan.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Geriatr Cardiol
JT  - Journal of geriatric cardiology : JGC
JID - 101237881
PMC - PMC4996836
OTO - NOTNLM
OT  - Brain natriuretic peptide
OT  - Heart failure
OT  - Physical frailty
OT  - Walking speed
EDAT- 2016/09/09 06:00
MHDA- 2016/09/09 06:01
PMCR- 2016/07/01
CRDT- 2016/09/09 06:00
PHST- 2016/09/09 06:00 [entrez]
PHST- 2016/09/09 06:00 [pubmed]
PHST- 2016/09/09 06:01 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - jgc-13-07-608 [pii]
AID - 10.11909/j.issn.1671-5411.2016.07.014 [doi]
PST - ppublish
SO  - J Geriatr Cardiol. 2016 Jul;13(7):608-14. doi: 
      10.11909/j.issn.1671-5411.2016.07.014.