PMID- 27606596
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20180910
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Linking)
VI  - 12
IP  - 2
DP  - 2018 Feb
TI  - Study on small airway function in asthmatics with fractional exhaled nitric oxide 
      and impulse oscillometry.
PG  - 483-490
LID - 10.1111/crj.12548 [doi]
AB  - OBJECTIVES: The invasive techniques can be direct and objective to assess small 
      airway function, but they have significant risks and inconveniences for patients 
      and cannot be repeated often. Some sophisticated techniques such as fractional 
      exhaled nitric oxide (FeNO) and impulse oscillometry (IOS) may surmount such 
      restrictions. Therefore, we investigated the relation among FeNO, IOS, and small 
      airway function in asthmatic patients. METHODS: We recruited 140 asthmatic 
      patients including 69 patients with small airway normal function and 71 patients 
      with small airway dysfunction. FeNO, eosinophil（EOS）count and total 
      immunoglobulin E (IgE) in peripheral blood, pulmonary function, as well as IOS 
      were measured. RESULTS: The levels of FeNO, the reactance area (AX), the resonant 
      frequency Fres and EOS were significantly increased in small airway dysfunction 
      group compared with small airway normal function group (P < 0.01 respectively). A 
      multiple regression model showed that FeNO, AX and Fres were correlative factors 
      of mid forced expiratory flow of percentages of predicted values [FEF25-75 
      (%pred)] (P < 0.01, respectively). A receiver operating characteristic (ROC) 
      analysis showed that the combination of FeNO, AX and Fres had a greater area 
      under the ROC curve (AUC) than each of them (AUC: 0.881, P < .001, 95％CI: 
      0.815-0.929). CONCLUSION: FeNO and IOS are helpful in diagnosis of small airway 
      dysfunction with high sensitivity and specificity, and FeNO combined with IOS can 
      better evaluate the small airway function in asthmatic patients.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Liu, Lin
AU  - Liu L
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Liu, Wen
AU  - Liu W
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
AD  - Department of Cadre Health Care, The Second Hospital of Shandong University, 
      Jinan, 250033, P.R. China.
FAU - Liu, Chunhong
AU  - Liu C
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Wang, Dexiang
AU  - Wang D
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Zhao, Jiping
AU  - Zhao J
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Wang, Junfei
AU  - Wang J
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Wu, Jinxiang
AU  - Wu J
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Liu, Tian
AU  - Liu T
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Zhang, Yuanyuan
AU  - Zhang Y
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Liu, Yahui
AU  - Liu Y
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Cao, Liuzhao
AU  - Cao L
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
FAU - Dong, Liang
AU  - Dong L
AD  - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, 
      250012, P.R. China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160928
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
RN  - 0 (Biomarkers)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Airway Remodeling/*physiology
MH  - Asthma/blood/*diagnosis/physiopathology
MH  - Biomarkers/blood
MH  - China/epidemiology
MH  - Eosinophils/cytology
MH  - Exhalation/physiology
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Lung/metabolism/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*analysis
MH  - Oscillometry/*instrumentation
MH  - Predictive Value of Tests
MH  - Respiratory Function Tests/methods
OTO - NOTNLM
OT  - asthma
OT  - fractional exhaled nitric oxide
OT  - impulse oscillometry
OT  - small airway dysfunction
EDAT- 2016/09/09 06:00
MHDA- 2018/09/11 06:00
CRDT- 2016/09/09 06:00
PHST- 2016/02/03 00:00 [received]
PHST- 2016/07/08 00:00 [revised]
PHST- 2016/08/30 00:00 [accepted]
PHST- 2016/09/09 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2016/09/09 06:00 [entrez]
AID - 10.1111/crj.12548 [doi]
PST - ppublish
SO  - Clin Respir J. 2018 Feb;12(2):483-490. doi: 10.1111/crj.12548. Epub 2016 Sep 28.