PMID- 27607426
OWN - NLM
STAT- MEDLINE
DCOM- 20170804
LR  - 20191210
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 9
DP  - 2016
TI  - Reproducibility and Validity of the 6-Minute Walk Test Using the Gait Real-Time 
      Analysis Interactive Lab in Patients with COPD and Healthy Elderly.
PG  - e0162444
LID - 10.1371/journal.pone.0162444 [doi]
LID - e0162444
AB  - BACKGROUND: The 6-minute walk test (6MWT) in a regular hallway is commonly used 
      to assess functional exercise capacity in patients with chronic obstructive 
      pulmonary disease (COPD). However, treadmill walking might provide additional 
      advantages over overground walking, especially if virtual reality and self-paced 
      treadmill walking are combined. Therefore, this study aimed to assess the 
      reproducibility and validity of the 6MWT using the Gait Real-time Analysis 
      Interactive Lab (GRAIL) in patients with COPD and healthy elderly. 
      METHODOLOGY/RESULTS: Sixty-one patients with COPD and 48 healthy elderly 
      performed two 6MWTs on the GRAIL. Patients performed two overground 6MWTs and 
      healthy elderly performed one overground test. Differences between consecutive 
      6MWTs and the test conditions (GRAIL vs. overground) were analysed. Patients 
      walked further in the second overground test (24.8 m, 95% CI 15.2-34.4 m, 
      p<0.001) and in the second GRAIL test (26.8 m, 95% CI 13.9-39.6 m). Healthy 
      elderly improved their second GRAIL test (49.6 m, 95% CI 37.0-62.3 m). The GRAIL 
      6MWT was reproducible (intra-class coefficients = 0.65-0.80). The best GRAIL 
      6-minute walk distance (6MWD) in patients was shorter than the best overground 
      6MWD (-27.3 +/- 49.1 m, p<0.001). Healthy elderly walked further on the GRAIL than 
      in the overground condition (23.6 +/- 41.4 m, p<0.001). Validity of the GRAIL 6MWT 
      was assessed and intra-class coefficient values ranging from 0.74-0.77 were 
      found. CONCLUSION: The GRAIL is a promising system to assess the 6MWD in patients 
      with COPD and healthy elderly. The GRAIL 6MWD seems to be more comparable to the 
      6MWDs assessed overground than previous studies on treadmills have reported. 
      Furthermore, good construct validity and reproducibility were established in 
      assessing the 6MWD using the GRAIL in patients with COPD and healthy elderly.
FAU - Liu, Wai-Yan
AU  - Liu WY
AUID- ORCID: 0000-0003-1379-958X
AD  - Department of Research and Education, CIRO, Horn, the Netherlands.
AD  - NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht 
      University Medical Centre+, Department of Human Movement Science, Maastricht, the 
      Netherlands.
FAU - Meijer, Kenneth
AU  - Meijer K
AD  - NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht 
      University Medical Centre+, Department of Human Movement Science, Maastricht, the 
      Netherlands.
FAU - Delbressine, Jeannet M
AU  - Delbressine JM
AD  - Department of Research and Education, CIRO, Horn, the Netherlands.
FAU - Willems, Paul J
AU  - Willems PJ
AD  - NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht 
      University Medical Centre+, Department of Human Movement Science, Maastricht, the 
      Netherlands.
FAU - Franssen, Frits M E
AU  - Franssen FM
AD  - Department of Research and Education, CIRO, Horn, the Netherlands.
AD  - Department of Respiratory Medicine, Maastricht University Medical Centre+, 
      Maastricht, the Netherlands.
FAU - Wouters, Emiel F M
AU  - Wouters EF
AD  - Department of Research and Education, CIRO, Horn, the Netherlands.
AD  - Department of Respiratory Medicine, Maastricht University Medical Centre+, 
      Maastricht, the Netherlands.
FAU - Spruit, Martijn A
AU  - Spruit MA
AD  - Department of Research and Education, CIRO, Horn, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20160908
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Computer Systems
MH  - Female
MH  - Gait/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology
MH  - Reproducibility of Results
MH  - *Walk Test
PMC - PMC5015964
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/09/09 06:00
MHDA- 2017/08/05 06:00
PMCR- 2016/09/08
CRDT- 2016/09/09 06:00
PHST- 2016/04/17 00:00 [received]
PHST- 2016/08/23 00:00 [accepted]
PHST- 2016/09/09 06:00 [entrez]
PHST- 2016/09/09 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2016/09/08 00:00 [pmc-release]
AID - PONE-D-16-15496 [pii]
AID - 10.1371/journal.pone.0162444 [doi]
PST - epublish
SO  - PLoS One. 2016 Sep 8;11(9):e0162444. doi: 10.1371/journal.pone.0162444. 
      eCollection 2016.