PMID- 27607899
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20221207
IS  - 1521-2254 (Electronic)
IS  - 1099-498X (Linking)
VI  - 18
IP  - 10
DP  - 2016 Oct
TI  - Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms and 
      diabetic retinopathy of type 2 diabetes mellitus in the Chinese Han population.
PG  - 282-287
LID - 10.1002/jgm.2926 [doi]
AB  - BACKGROUND: Diabetic retinopathy (DR) is one of the most common microvascular 
      complications of diabetes. The present study aimed to identify a possible 
      connection between gene polymorphisms and the risk of developing DR. MATERIALS 
      AND METHODS: A total of 319 patients with type 2 diabetes mellitus (T2DM) were 
      selected. All patients underwent a complete eye examination. Based on this, the 
      patients with T2DM were divided into two subgroups: 175 patients with retinopathy 
      (DR) and 144 patients without retinopathy (NDR). We calculated the genotype 
      frequencies of case and control subjects using the chi-squares test. The odds 
      ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional 
      logistic regression adjusted for age and sex. RESULTS: The finding by analysis is 
      that the mean of duration of diabetes, total cholesterol (TC), triglycerides 
      (TG), low-density lipoprotein (LDL), glomerular filtration rate and C-peptide 
      were significantly different between DR and NDR. We found significant differences 
      in cystatin-C concentrations with LEKR1-CCNL1 rs13064954 and NOS3 rs3918227 of 
      different genotypes. Significant differences in serum TG levels were seen among 
      the three genotypes of MTHFR rs1537516. Subjects carried the T allele of 
      IGSF21-KLHDC7A rs3007729 had higher serum LDL concentrations (p = 0.015). In the 
      allele model, LEKR1-CCNL1 rs13064954 decreased the risk of DR (OR =0.57, 95% 
      CI = 0.34-0.96, p = 0.032). Under the dominant model, the IGSF21-KLHDC7A 
      rs3007729 CT-TT genotype increased the risk of DR (OR =1.84, 95% CI = 1.14-2.99, 
      p = 0.013). CONCLUSIONS: Our results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A 
      influence the development of DR.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Lin, Xiaohui
AU  - Lin X
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China. Xiaoh_lin@163.com.
FAU - Wang, Jihong
AU  - Wang J
AD  - Department of Hand and Microsurgery II, the Second Affiliated Hospital of Inner 
      Mongolia Medical University, Hohhot, China.
FAU - Yun, Lixia
AU  - Yun L
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
FAU - Jiang, Shuhong
AU  - Jiang S
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
FAU - Li, Langen
AU  - Li L
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
FAU - Chen, Xiaohai
AU  - Chen X
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
FAU - Li, Zhen
AU  - Li Z
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
FAU - Lu, Qiang
AU  - Lu Q
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
FAU - Zhang, Yihui
AU  - Zhang Y
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
FAU - Ma, Xiaocheng
AU  - Ma X
AD  - Department of Ophthalmology, The Inner Mongolia Autonomous Region People's 
      Hospital, Hohhot, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Gene Med
JT  - The journal of gene medicine
JID - 9815764
RN  - 0 (CCNL1 protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cyclins)
RN  - 0 (LEKR1 protein, human)
RN  - 0 (Lipids)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Carrier Proteins/*genetics
MH  - China
MH  - Cyclins/*genetics
MH  - Diabetes Mellitus, Type 2/complications/ethnology/*genetics
MH  - Diabetic Retinopathy/ethnology/etiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Proteins/*genetics
MH  - Ubiquitin-Protein Ligases/*genetics
OTO - NOTNLM
OT  - IGSF21-KLHDC7A
OT  - diabetic retinopathy
OT  - polymorphism LEKR1-CCNL1
OT  - type 2 diabetes mellitus
EDAT- 2016/11/01 06:00
MHDA- 2018/01/31 06:00
CRDT- 2016/09/09 06:00
PHST- 2016/07/28 00:00 [received]
PHST- 2016/08/21 00:00 [revised]
PHST- 2016/09/06 00:00 [accepted]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
PHST- 2016/09/09 06:00 [entrez]
AID - 10.1002/jgm.2926 [doi]
PST - ppublish
SO  - J Gene Med. 2016 Oct;18(10):282-287. doi: 10.1002/jgm.2926.