PMID- 27608302
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20240109
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 40
DP  - 2016 Nov
TI  - In vivo and in vitro inhibitory activity of an ethanolic extract of Sargassum 
      fulvellum and its component grasshopper ketone on atopic dermatitis.
PG  - 176-183
LID - S1567-5769(16)30285-5 [pii]
LID - 10.1016/j.intimp.2016.07.015 [doi]
AB  - The present study investigated the effect of Sargassum fulvellum ethanol extract 
      (SFEE) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like 
      skin lesions in BALB/c mice. The severity of skin dermatitis, production of 
      cytokines, and total IgE content were measured, and the histopathological 
      features were analyzed. SFEE decreased the severity of DNCB-induced dermatitis 
      and suppressed the serum levels of total immunoglobulin E (IgE), tumor necrosis 
      factor (TNF)-alpha, and interleukin (IL)-4. In addition, SFEE reduced the production 
      of IL-4, IL-5, and IL-13 in mice splenocytes. However, the levels of IL-10 and 
      interferon (IFN)-gamma significantly increased in mice sera and splenocytes. 
      Histological examination revealed decreased dermal thickness and infiltration by 
      mast cells after treatment with SFEE. Furthermore, grasshopper ketone, a compound 
      isolated from SFEE, was found to significantly decrease cytokine production in 
      concanavalin A-stimulated splenocytes from BALB/c mice with no cytotoxicity. 
      Taken together, these results indicate that SFEE and the isolated grasshopper 
      ketone have an inhibitory effect on AD by regulating immune mediators and cells 
      and may be a potential effective alternative therapy for AD.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Kang, Bo-Kyeong
AU  - Kang BK
AD  - Department of Food Science & Technology/Institute of Food Science, Pukyong 
      National University, Busan 608-737, Republic of Korea.
FAU - Kim, Min-Ji
AU  - Kim MJ
AD  - Department of Food Science & Technology/Institute of Food Science, Pukyong 
      National University, Busan 608-737, Republic of Korea.
FAU - Kim, Koth-Bong-Woo-Ri
AU  - Kim KB
AD  - Institute of Fisheries Sciences, Pukyong National University, Busan 619-911, 
      Republic of Korea.
FAU - Ahn, Dong-Hyun
AU  - Ahn DH
AD  - Department of Food Science & Technology/Institute of Food Science, Pukyong 
      National University, Busan 608-737, Republic of Korea. Electronic address: 
      dhahn@pknu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20160905
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Alkadienes)
RN  - 0 (Cyclohexanols)
RN  - 0 (Cytokines)
RN  - 0 (Mitogens)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 0 (grasshopper ketone)
RN  - 11028-71-0 (Concanavalin A)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alkadienes/pharmacology/*therapeutic use
MH  - Animals
MH  - Concanavalin A/pharmacology
MH  - Cyclohexanols/pharmacology/*therapeutic use
MH  - Cytokines/blood
MH  - Dermatitis, Atopic/blood/*drug therapy/immunology/pathology
MH  - Ethanol/chemistry
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Mitogens/pharmacology
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - *Sargassum
MH  - Skin/pathology
MH  - Solvents/chemistry
MH  - Spleen/cytology
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Cytokines
OT  - Grasshopper ketone
OT  - IgE
OT  - Sargassum fulvellum
EDAT- 2016/09/09 06:00
MHDA- 2017/05/16 06:00
CRDT- 2016/09/09 06:00
PHST- 2015/04/08 00:00 [received]
PHST- 2016/07/15 00:00 [revised]
PHST- 2016/07/16 00:00 [accepted]
PHST- 2016/09/09 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/09/09 06:00 [entrez]
AID - S1567-5769(16)30285-5 [pii]
AID - 10.1016/j.intimp.2016.07.015 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2016 Nov;40:176-183. doi: 10.1016/j.intimp.2016.07.015. Epub 
      2016 Sep 5.