PMID- 27608594
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20180508
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 222
IP  - 10
DP  - 2017 Oct
TI  - PLA2G2A polymorphisms are associated with metabolic syndrome and type 2 diabetes 
      mellitus. Results from the genetics of atherosclerotic disease Mexican study.
PG  - 967-972
LID - S0171-2985(16)30361-8 [pii]
LID - 10.1016/j.imbio.2016.08.014 [doi]
AB  - The secretory phospholipase A(2) II A (sPLA(2)-IIA) encoded by PLA2G2A gene 
      hydrolyzes phospholipids liberating free fatty acids (FFAs) and 
      lysophospholipids. If lipolysis exceeds lipogenesis, the free fatty acids undergo 
      a continuous release into circulation. A sustained excessive increase in this 
      release contributes to metabolic disease. The aim of the present study was to 
      evaluate the role of PLA2G2A gene polymorphisms as susceptibility markers for 
      metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) in Mexican 
      population. Three PLA2G2A gene polymorphisms (rs876018, rs3753827 and rs11573156) 
      were genotyped by 5' exonuclease TaqMan assays in a group of 338 patients with 
      T2DM, 460 individuals with MetS and 366 healthy controls. Under codominant 
      1(codom1), dominant (dom) and additive (add) models adjusted by age, gender, body 
      mass index (BMI), smoking habit, and hypertension, the rs876018T allele was 
      associated with increased risk of MetS [Odds Ratio (OR)=1.66, P(codom1)=0.005; 
      OR=1.67, P(dom)=0.003; OR=1.49, P(add)=0.005] as compared to controls. On the 
      other hand, under several models adjusted by the same variables, the rs3753827A 
      (OR=1.52, P(codom1)=0.039 and OR=1.49, P(dom)=0.039) and rs11573156C alleles 
      (OR=6.46, P(codom1)=0.013; OR=6.70, P(codom2)=0.009; OR=6.65, P(dom)=0.009) were 
      associated with increased risk of T2DM when compared with controls. In addition, 
      the rs876018T allele was associated with hypercholesterolemia (P(dom)=0.017, 
      P(add)=0.009) and risk of subclinical atherosclerosis (SA) (P(dom)=0.041) in MetS 
      when compared with controls. Also, this allele was associated with SA in T2DM 
      patients (P(dom)=0.007). The TAG haplotype was significantly associated with 
      increased risk of MetS (OR=1.54, P=0.006). Results suggest that PLA2G2A 
      polymorphisms are involved in the risk of developing MetS and T2D and are 
      associated with SA in this group of patients.
CI  - Copyright (c) 2016 Elsevier GmbH. All rights reserved.
FAU - Monroy-Munoz, Irma Eloisa
AU  - Monroy-Munoz IE
AD  - Department of Human Genetics and Genomics, Instituto Nacional de Perinatologia 
      Isidro Espinoza de los Reyes, Mexico City, Mexico.
FAU - Angeles-Martinez, Javier
AU  - Angeles-Martinez J
AD  - Department of Molecular Biology, Instituto Nacional de Cardiologia Ignacio 
      Chavez, Mexico City, Mexico.
FAU - Posadas-Sanchez, Rosalinda
AU  - Posadas-Sanchez R
AD  - Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico City, Mexico.
FAU - Villarreal-Molina, Teresa
AU  - Villarreal-Molina T
AD  - Cardiovascular Genomics Laboratory, Instituto Nacional de Medicina Genomica 
      (INMEGEN), Mexico City, Mexico.
FAU - Alvarez-Leon, Edith
AU  - Alvarez-Leon E
AD  - Department of Molecular Biology, Instituto Nacional de Cardiologia Ignacio 
      Chavez, Mexico City, Mexico.
FAU - Flores-Dominguez, Carmina
AU  - Flores-Dominguez C
AD  - CICSA, Universidad Anahuac, Mexico.
FAU - Cardoso-Saldana, Guillermo
AU  - Cardoso-Saldana G
AD  - Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico City, Mexico.
FAU - Medina-Urrutia, Aida
AU  - Medina-Urrutia A
AD  - Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico City, Mexico.
FAU - Juarez-Rojas, Juan Gabriel
AU  - Juarez-Rojas JG
AD  - Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico City, Mexico.
FAU - Posadas-Romero, Carlos
AU  - Posadas-Romero C
AD  - Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico City, Mexico.
FAU - Alarcon, Gilberto Vargas
AU  - Alarcon GV
AD  - Department of Molecular Biology, Instituto Nacional de Cardiologia Ignacio 
      Chavez, Mexico City, Mexico. Electronic address: gvargas63@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160903
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - EC 3.1.1.4 (Group II Phospholipases A2)
RN  - EC 3.1.1.4 (PLA2G2A protein, human)
SB  - IM
MH  - Atherosclerosis/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Group II Phospholipases A2/*genetics
MH  - Humans
MH  - Hypercholesterolemia/*genetics
MH  - Linkage Disequilibrium
MH  - Lipogenesis
MH  - Lipolysis
MH  - Metabolic Syndrome/*genetics
MH  - Mexico
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Metabolic syndrome
OT  - Polymorphisms
OT  - Secretory phospholipase A(2) II A
OT  - Subclinical atherosclerosis
OT  - Type 2 diabetes mellitus
EDAT- 2016/09/10 06:00
MHDA- 2018/05/01 06:00
CRDT- 2016/09/10 06:00
PHST- 2015/12/16 00:00 [received]
PHST- 2016/07/25 00:00 [revised]
PHST- 2016/08/30 00:00 [accepted]
PHST- 2016/09/10 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2016/09/10 06:00 [entrez]
AID - S0171-2985(16)30361-8 [pii]
AID - 10.1016/j.imbio.2016.08.014 [doi]
PST - ppublish
SO  - Immunobiology. 2017 Oct;222(10):967-972. doi: 10.1016/j.imbio.2016.08.014. Epub 
      2016 Sep 3.