PMID- 27609275
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20221207
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 298
DP  - 2016 Sep 15
TI  - Autoantibody profile and clinical characteristics in a cohort of Chinese adult 
      myasthenia gravis patients.
PG  - 51-7
LID - S0165-5728(16)30144-8 [pii]
LID - 10.1016/j.jneuroim.2016.07.001 [doi]
AB  - Myasthenia gravis (MG) is an autoimmune disorder with heterogeneity. Antibodies 
      against acetylcholine receptor (AChR), muscle-specific kinase (MuSK), titin and 
      ryanodine receptor (RyR) were examined in 437 adult Chinese MG patients. The 
      AChR, MuSK, titin and RyR antibodies were found in 82.2%, 2.3%, 28.4% and 23.8% 
      of all patients. Autoantibody profiles vary among different MG subgroups. Thymoma 
      MG patients had high frequencies of AChR (99.2%), titin (50.8%) and RyR 
      antibodies (46.9%). The titin and RyR antibodies also showed high frequencies in 
      late onset patients (54.4% and 33.3%, respectively). These two antibodies may 
      indicate an underlying thymoma when combined. The patients with titin and RyR 
      antibodies tend to have more severe disease and worse outcome, and may need more 
      active immunosuppressive treatment.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Hong, Yu
AU  - Hong Y
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
FAU - Li, Hai-Feng
AU  - Li HF
AD  - Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
FAU - Skeie, Geir Olve
AU  - Skeie GO
AD  - Department of Neurology, Haukeland University Hospital, Bergen, Norway.
FAU - Romi, Fredrik
AU  - Romi F
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department 
      of Neurology, Haukeland University Hospital, Bergen, Norway.
FAU - Hao, Hong-Jun
AU  - Hao HJ
AD  - Department of Neurology, Peking University First Hospital, Beijing, China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Gao, Xiang
AU  - Gao X
AD  - Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Owe, Jone Furlund
AU  - Owe JF
AD  - Department of Neurology, Haukeland University Hospital, Bergen, Norway.
FAU - Gilhus, Nils Erik
AU  - Gilhus NE
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department 
      of Neurology, Haukeland University Hospital, Bergen, Norway. Electronic address: 
      nils.gilhus@helse-bergen.no.
LA  - eng
PT  - Journal Article
DEP - 20160702
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (ACD protein, human)
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Ryanodine Receptor Calcium Release Channel)
RN  - 0 (Shelterin Complex)
RN  - 0 (Telomere-Binding Proteins)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Autoantibodies/*metabolism
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/complications/*immunology
MH  - Radioimmunoassay
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
MH  - Retrospective Studies
MH  - Ryanodine Receptor Calcium Release Channel/*immunology
MH  - Severity of Illness Index
MH  - Shelterin Complex
MH  - Telomere-Binding Proteins/immunology
MH  - Thymoma/complications/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Muscle-specific kinase antibodies
OT  - Myasthenia gravis
OT  - Ryanodine receptor antibodies
OT  - Thymoma
OT  - Titin antibodies
EDAT- 2016/09/10 06:00
MHDA- 2017/08/18 06:00
CRDT- 2016/09/10 06:00
PHST- 2016/02/22 00:00 [received]
PHST- 2016/06/27 00:00 [revised]
PHST- 2016/07/01 00:00 [accepted]
PHST- 2016/09/10 06:00 [entrez]
PHST- 2016/09/10 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
AID - S0165-5728(16)30144-8 [pii]
AID - 10.1016/j.jneuroim.2016.07.001 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2016 Sep 15;298:51-7. doi: 10.1016/j.jneuroim.2016.07.001. Epub 
      2016 Jul 2.