PMID- 2760947
OWN - NLM
STAT- MEDLINE
DCOM- 19890920
LR  - 20190711
IS  - 0022-5282 (Print)
IS  - 0022-5282 (Linking)
VI  - 29
IP  - 8
DP  - 1989 Aug
TI  - Isoproterenol inhibits the increase in microvascular membrane permeability 
      produced by bradykinin.
PG  - 1053-63; discussion 1063-4
AB  - Bradykinin (BRADY) is hypothesized to cause the "capillary leak" syndrome in 
      patients with sepsis, trauma, and burns. Our purpose was to determine if 
      isoproterenol (ISO) reversed a BRADY-produced accelerated loss of intravascular 
      fluid and protein into the interstitium of skin. An increase in microvascular 
      permeability in canine hind paw skin was sustained by a continuous femoral artery 
      infusion of BRADY (0.2 micrograms/kg/min). After 2 hours of BRADY, skin lymph 
      flow (LYM FLOW microliters/min) increased nine-fold and skin lymph-to-plasma 
      total protein concentration ratio (RTP) was substantially increased. Mean blood 
      flow in the femoral arteries was increased four-fold by the BRADY infusion. After 
      2 hours of BRADY-induced increased permeability, five of the ten dogs were 
      started on intravenous ISO (2 micrograms/min continuously) which increased heart 
      rate from 182 +/- 15 to 222 +/- 11 beats/min. ISO reversed the increase in RTP 
      produced by the BRADY. After 8 hours of BRADY, there was less tissue albumin in 
      the dogs given ISO (14.5 +/- 2.0 vs. 29.5 +/- 6.6 mg/gram dry wgt, p less than 
      0.05 unpaired t-test). ISO can reverse the sustained increase in skin 
      microvascular permeability produced by BRADY.
FAU - Mullins, R J
AU  - Mullins RJ
AD  - Department of Surgery, University of Louisville Medical School, Kentucky.
FAU - Malias, M A
AU  - Malias MA
FAU - Hudgens, R W
AU  - Hudgens RW
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
RN  - 0 (Blood Proteins)
RN  - L628TT009W (Isoproterenol)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Animals
MH  - Blood Proteins/analysis
MH  - Bradykinin/*pharmacology
MH  - Cell Membrane Permeability/*drug effects
MH  - Dogs
MH  - Drug Interactions
MH  - Femoral Artery/drug effects/physiology
MH  - Infusions, Intra-Arterial
MH  - Infusions, Intravenous
MH  - Isoproterenol/*pharmacology
MH  - Lymph/analysis/drug effects
MH  - Lymphatic System/*drug effects
MH  - Male
MH  - Regional Blood Flow/drug effects
MH  - Skin/blood supply/*drug effects
MH  - Time Factors
EDAT- 1989/08/01 00:00
MHDA- 1989/08/01 00:01
CRDT- 1989/08/01 00:00
PHST- 1989/08/01 00:00 [pubmed]
PHST- 1989/08/01 00:01 [medline]
PHST- 1989/08/01 00:00 [entrez]
AID - 10.1097/00005373-198908000-00002 [doi]
PST - ppublish
SO  - J Trauma. 1989 Aug;29(8):1053-63; discussion 1063-4. doi: 
      10.1097/00005373-198908000-00002.