PMID- 27610347
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160909
LR  - 20200929
IS  - 2219-2808 (Print)
IS  - 2219-2808 (Electronic)
IS  - 2219-2808 (Linking)
VI  - 5
IP  - 3
DP  - 2016 Aug 8
TI  - Subclinical hypothyroidism in atopic South Italian children.
PG  - 306-10
LID - 10.5409/wjcp.v5.i3.306 [doi]
AB  - AIM: To verify if subclinical hypothyroidism (SCH) could be associated to atopy 
      in children. METHODS: Seven hundred and thirty-two Caucasian children from South 
      Italy presenting symptoms of allergic disease were enrolled and submitted to 
      atopy, obesity, chronic low grade inflammation, and SCH work up. RESULTS: Four 
      hundred and forty-five out of 705 (63.12%) children affected by allergic disease 
      were diagnosed as atopic and 260 (36.88%) as not atopic. The SCH prevalence was 
      6.3%. Significant higher prevalence of SCH among atopic children with average 
      (group 2) and high (group 3) low grade chronic inflammation compared to atopic 
      children with mild (group 1) low grade chronic inflammation was present. 
      Moreover, group 1 and group 2 presented an OR to show SCH of 2.57 (95%CI: 
      1.55-6.26) and 2.96 (95%CI: 1.01-8.65), respectively. Both in atopic and not 
      atopic children we found C3 serum levels significantly higher in group 3 respect 
      to group 2 and group 1. Noteworthy, among atopic patients, also total 
      immunoglobulin E (IgE) serum levels, were significantly higher in group 3 
      compared to group 2 and group 1 children. In atopic children, C3 and total IgE 
      serum values increased in parallel with the increase of C-reactive protein 
      values, while in not atopic children this phenomenon was not evident. CONCLUSION: 
      The possibility exists that an increasing atopic inflammation contributes to SCH 
      occurrence. So far this is the first report in literature showing an association 
      between SCH and atopy but further studies are needed to confirm our data.
FAU - Pedulla, Marcella
AU  - Pedulla M
AD  - Marcella Pedulla, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna 
      Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, 
      Child and General and Specialized Surgery, Seconda Universita degli Studi di 
      Napoli, 80138 Napoli, Italy.
FAU - Fierro, Vincenzo
AU  - Fierro V
AD  - Marcella Pedulla, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna 
      Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, 
      Child and General and Specialized Surgery, Seconda Universita degli Studi di 
      Napoli, 80138 Napoli, Italy.
FAU - Marzuillo, Pierluigi
AU  - Marzuillo P
AD  - Marcella Pedulla, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna 
      Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, 
      Child and General and Specialized Surgery, Seconda Universita degli Studi di 
      Napoli, 80138 Napoli, Italy.
FAU - Del Tufo, Ester
AU  - Del Tufo E
AD  - Marcella Pedulla, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna 
      Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, 
      Child and General and Specialized Surgery, Seconda Universita degli Studi di 
      Napoli, 80138 Napoli, Italy.
FAU - Grandone, Anna
AU  - Grandone A
AD  - Marcella Pedulla, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna 
      Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, 
      Child and General and Specialized Surgery, Seconda Universita degli Studi di 
      Napoli, 80138 Napoli, Italy.
FAU - Perrone, Laura
AU  - Perrone L
AD  - Marcella Pedulla, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna 
      Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, 
      Child and General and Specialized Surgery, Seconda Universita degli Studi di 
      Napoli, 80138 Napoli, Italy.
FAU - Miraglia Del Giudice, Emanuele
AU  - Miraglia Del Giudice E
AD  - Marcella Pedulla, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna 
      Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, 
      Child and General and Specialized Surgery, Seconda Universita degli Studi di 
      Napoli, 80138 Napoli, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160808
PL  - United States
TA  - World J Clin Pediatr
JT  - World journal of clinical pediatrics
JID - 101627548
PMC - PMC4978624
OTO - NOTNLM
OT  - Atopy
OT  - Children
OT  - Low grade chronic inflammation
OT  - Subclinical hypothyroidism
OT  - Thyroid derangement
EDAT- 2016/09/10 06:00
MHDA- 2016/09/10 06:01
PMCR- 2016/08/08
CRDT- 2016/09/10 06:00
PHST- 2016/03/01 00:00 [received]
PHST- 2016/03/29 00:00 [revised]
PHST- 2016/04/14 00:00 [accepted]
PHST- 2016/09/10 06:00 [entrez]
PHST- 2016/09/10 06:00 [pubmed]
PHST- 2016/09/10 06:01 [medline]
PHST- 2016/08/08 00:00 [pmc-release]
AID - 10.5409/wjcp.v5.i3.306 [doi]
PST - epublish
SO  - World J Clin Pediatr. 2016 Aug 8;5(3):306-10. doi: 10.5409/wjcp.v5.i3.306. 
      eCollection 2016 Aug 8.