PMID- 27610390
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and 
      Adaptive Immune Responses.
PG  - 6264149
LID - 10.1155/2016/6264149 [doi]
LID - 6264149
AB  - Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus 
      (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. 
      T2DM is known to potentiate CAD which had led to the coining of a new clinical 
      entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. 
      The synergistic interaction between these two comorbidities is through sterile 
      inflammation which is now being addressed as metabolic inflammation or 
      metainflammation, which plays a pivotal role during both early and late stages of 
      T2DM and also serves as a link between T2DM and CAD. This review summarises the 
      current concepts on the role played by both innate and adaptive immune responses 
      in setting up metainflammation in DM-CAD. More specifically, the role played by 
      innate pattern recognition receptors (PRRs) like Toll-like receptors (TLRs), 
      NOD1-like receptors (NLRs), Rig-1-like receptors (RLRs), and C-type lectin like 
      receptors (CLRs) and metabolic endotoxemia in fuelling metainflammation in DM-CAD 
      would be discussed. Further, the role played by adaptive immune cells (Th1, Th2, 
      Th17, and Th9 cells) in fuelling metainflammation in DM-CAD will also be 
      discussed.
FAU - Aravindhan, Vivekanandhan
AU  - Aravindhan V
AUID- ORCID: 0000-0002-5639-4948
AD  - Department of Genetics, Dr. ALM. PG. IBMS, University of Madras, Chennai 600113, 
      India.
FAU - Madhumitha, Haridoss
AU  - Madhumitha H
AD  - AU-KBC Research Centre, MIT Campus of Anna University, Chennai 600044, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160816
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Lectins, C-Type)
RN  - 0 (NLR Proteins)
RN  - 0 (Receptors, Pattern Recognition)
RN  - 0 (Toll-Like Receptors)
RN  - EC 3.6.4.13 (DEAD Box Protein 58)
SB  - IM
MH  - Adaptive Immunity/*immunology
MH  - Coronary Artery Disease/etiology/*immunology
MH  - DEAD Box Protein 58/immunology
MH  - Diabetes Mellitus, Type 2/complications/*immunology
MH  - Humans
MH  - Immunity, Innate/*immunology
MH  - Inflammation/*immunology
MH  - Lectins, C-Type/immunology
MH  - NLR Proteins/immunology
MH  - Receptors, Pattern Recognition/immunology
MH  - T-Lymphocytes/*immunology
MH  - Th1 Cells/immunology
MH  - Th17 Cells/immunology
MH  - Th2 Cells/immunology
MH  - Toll-Like Receptors/immunology
PMC - PMC5004008
EDAT- 2016/09/10 06:00
MHDA- 2017/06/07 06:00
PMCR- 2016/08/16
CRDT- 2016/09/10 06:00
PHST- 2016/05/19 00:00 [received]
PHST- 2016/07/19 00:00 [accepted]
PHST- 2016/09/10 06:00 [entrez]
PHST- 2016/09/10 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
PHST- 2016/08/16 00:00 [pmc-release]
AID - 10.1155/2016/6264149 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:6264149. doi: 10.1155/2016/6264149. Epub 2016 Aug 16.