PMID- 27611703 OWN - NLM STAT- MEDLINE DCOM- 20170526 LR - 20170526 IS - 1537-2995 (Electronic) IS - 0041-1132 (Linking) VI - 56 IP - 10 DP - 2016 Oct TI - Blood group A mothers are more likely to develop anemia during antenatal intravenous immunoglobulin treatment of fetal and neonatal alloimmune thrombocytopenia. PG - 2449-2454 LID - 10.1111/trf.13779 [doi] AB - BACKGROUND: Incompatibility between parental platelet (PLT) antigens may lead to sensitization of mother and development of fetal and neonatal alloimmune thrombocytopenia (FNAIT) resulting in fetal thrombocytopenia. Intravenous immunoglobulin (IVIG) with or without prednisone is the most effective, evidence-based antenatal treatment for subsequent FNAIT-affected pregnancies. IVIG infusion causes hemolysis in other settings, the degree depending upon patient blood groups (BGs). STUDY DESIGN AND METHODS: In ClinicalTrials.gov NCT00194987, 102 pregnant women received randomized antenatal treatment: Arm A received 2 g/kg/week IVIG; Arm B received 1 g/kg/week IVIG + 0.5 mg/kg/day prednisone. This post hoc analysis explored BG and anemia in 69 FNAIT mothers treated with Arm A or Arm B without salvage treatment to explore the effects of IVIG and steroid treatment on development of anemia in these women. Mothers whose treatment changed, for example, those with insufficient or unknown fetal PLT response who received salvage therapy, were excluded. RESULTS: For Arm A, 17 of 21 (hemoglobin [Hb] < 10 g/dL) mothers with anemia but only three of 15 mothers without anemia had BG-A and/or BG-B (p = 0.0005). BG was unrelated to anemia in Arm B; only nine of 33 Arm B mothers became anemic during treatment. The mean decrease in Hb level in women with BG-non-O was 1.9 g/dL and in women with BG-O was 1.1 g/dL (p = 0.004). Anemia was not caused by iron deficiency; the lowest mean corpuscular volume was 79. CONCLUSION: FNAIT women with BG-non-O more frequently develop anemia secondary to high-dose IVIG infusion (2 g/kg/week), quite possibly from isohemagglutinin-mediated hemolysis; maternal Hb requires monitoring. IVIG at 1 g/kg/week did not cause anemia in women with BG-non-O; concomitant prednisone likely alleviated the IVIG effect. Maternal BG could influence selection of antenatal treatment for FNAIT. CI - (c) 2016 AABB. FAU - Lakkaraja, Madhavi AU - Lakkaraja M AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. FAU - Jin, Jenny C AU - Jin JC AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. FAU - Manotas, Karen C AU - Manotas KC AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. FAU - Vinograd, Cheryl A AU - Vinograd CA AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. FAU - Ferd, Polina AU - Ferd P AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. FAU - Gabor, Julia AU - Gabor J AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. FAU - Wissert, Megan AU - Wissert M AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. FAU - Berkowitz, Richard L AU - Berkowitz RL AD - Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York. FAU - McFarland, Janice G AU - McFarland JG AD - Platelet and Neutrophil Immunology Laboratory, Blood Center of Wisconsin, Milwaukee, Wisconsin. AD - Department of Medicine, Division of Hematology-Oncology, Medical College of Wisconsin, Wauwatosa, Wisconsin. FAU - Bussel, James B AU - Bussel JB AD - Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University. jbussel@med.cornell.edu. LA - eng SI - ClinicalTrials.gov/NCT00194987 PT - Journal Article PT - Randomized Controlled Trial DEP - 20160909 PL - United States TA - Transfusion JT - Transfusion JID - 0417360 RN - 0 (Blood Group Antigens) RN - 0 (Hemoglobins) RN - 0 (Immunoglobulins, Intravenous) RN - 0 (Steroids) RN - VB0R961HZT (Prednisone) SB - IM MH - Anemia/chemically induced/*etiology/immunology MH - *Blood Group Antigens MH - Female MH - Hemoglobins/analysis MH - Humans MH - Immunoglobulins, Intravenous/*administration & dosage/adverse effects MH - Mothers MH - Prednisone/pharmacology/therapeutic use MH - Pregnancy MH - Steroids/pharmacology/therapeutic use MH - Thrombocytopenia, Neonatal Alloimmune/*drug therapy MH - Treatment Outcome EDAT- 2016/09/10 06:00 MHDA- 2017/05/27 06:00 CRDT- 2016/09/10 06:00 PHST- 2016/01/05 00:00 [received] PHST- 2016/04/28 00:00 [revised] PHST- 2016/05/26 00:00 [accepted] PHST- 2016/09/10 06:00 [pubmed] PHST- 2017/05/27 06:00 [medline] PHST- 2016/09/10 06:00 [entrez] AID - 10.1111/trf.13779 [doi] PST - ppublish SO - Transfusion. 2016 Oct;56(10):2449-2454. doi: 10.1111/trf.13779. Epub 2016 Sep 9.