PMID- 27611743
OWN - NLM
STAT- MEDLINE
DCOM- 20180201
LR  - 20180201
IS  - 1525-6073 (Electronic)
IS  - 0742-0528 (Linking)
VI  - 33
IP  - 10
DP  - 2016
TI  - Can the circadian phase be estimated from self-reported sleep timing in patients 
      with Delayed Sleep Wake Phase Disorder to guide timing of chronobiologic 
      treatment?
PG  - 1376-1390
AB  - INTRODUCTION: The efficacy of bright light and/or melatonin treatment for Delayed 
      Sleep Wake Phase Disorder (DSWPD) is contingent upon an accurate clinical 
      assessment of the circadian phase. However, the process of determining this 
      circadian phase can be costly and is not yet readily available in the clinical 
      setting. The present study investigated whether more cost-effective and 
      convenient estimates of the circadian phase, such as self-reported sleep timing, 
      can be used to predict the circadian phase and guide the timing of light and/or 
      melatonin treatment (i.e. dim-light melatonin onset, core body temperature 
      minimum and melatonin secretion mid-point) in a sample of individuals with DSWPD. 
      METHOD: Twenty-four individuals (male = 17; mean age = 21.96, SD = 5.11) with 
      DSWPD were selected on the basis of ICSD-3 criteria from a community-based 
      sample. The first 24-hours of a longer 80-hour constant laboratory ultradian 
      routine were used to determine core body temperature minimum (cBT(min)), 
      dim-light melatonin onset (DLMO) and the midpoint of the melatonin secretion 
      period (DLM(mid) = [DLM degrees (ff)-DLMO]/2). Prior to the laboratory session subjective 
      sleep timing was assessed using a 7-day sleep/wake diary, the Pittsburgh Sleep 
      Quality Index (PSQI), and the Delayed Sleep Phase Disorder Sleep Timing 
      Questionnaire (DSPD-STQ). RESULTS: Significant moderate to strong positive 
      correlations were observed between self-reported sleep timing variables and DLMO, 
      cBT(min) and DLM(mid). Regression equations revealed that the circadian phase 
      (DLMO, cBT(min) and DLM(mid)) was estimated within +/-1.5 hours of the measured 
      circadian phase most accurately by the combination of sleep timing measures (88% 
      of the sample) followed by sleep diary reported midsleep (83% of the sample) and 
      sleep onset time (79% of the sample). DISCUSSION: These findings suggest that 
      self-reported sleep timing may be useful clinically to predict a therapeutically 
      relevant circadian phase in DSWPD.
FAU - Lovato, Nicole
AU  - Lovato N
AD  - a Adelaide Institute for Sleep Health: A Flinders Centre for Research Excellence 
      , Flinders University of South Australia , Adelaide , South Australia.
FAU - Micic, Gorica
AU  - Micic G
AD  - b Flinders University of South Australia , Adelaide , South Australia.
FAU - Gradisar, Michael
AU  - Gradisar M
AD  - b Flinders University of South Australia , Adelaide , South Australia.
FAU - Ferguson, Sally A
AU  - Ferguson SA
AD  - c Appleton Institute , Central Queensland University , Adelaide , South 
      Australia.
FAU - Burgess, Helen J
AU  - Burgess HJ
AD  - d Biological Rhythms Research Laboratory Rush University Medical Center , Chicago 
      , IL , USA.
FAU - Kennaway, David J
AU  - Kennaway DJ
AD  - e Robinson Research Institute, School of Medicine, Discipline of Obstetrics and 
      Gynaecology , University of Adelaide , Adelaide , South Australia.
FAU - Lack, Leon
AU  - Lack L
AD  - a Adelaide Institute for Sleep Health: A Flinders Centre for Research Excellence 
      , Flinders University of South Australia , Adelaide , South Australia.
AD  - b Flinders University of South Australia , Adelaide , South Australia.
LA  - eng
PT  - Journal Article
DEP - 20160909
PL  - England
TA  - Chronobiol Int
JT  - Chronobiology international
JID - 8501362
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Adult
MH  - Body Temperature/drug effects
MH  - Circadian Rhythm/*drug effects/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Melatonin/administration & dosage/*pharmacology
MH  - *Self Report
MH  - Sleep/*drug effects/physiology
MH  - Sleep Wake Disorders/*drug therapy
MH  - Time Factors
OTO - NOTNLM
OT  - Chronobiologic treatment
OT  - Circadian phase
OT  - Delayed Sleep Wake Phase Disorder
OT  - self-reported sleep timing
EDAT- 2016/09/10 06:00
MHDA- 2018/02/02 06:00
CRDT- 2016/09/10 06:00
PHST- 2016/09/10 06:00 [pubmed]
PHST- 2018/02/02 06:00 [medline]
PHST- 2016/09/10 06:00 [entrez]
AID - 10.1080/07420528.2016.1220386 [doi]
PST - ppublish
SO  - Chronobiol Int. 2016;33(10):1376-1390. doi: 10.1080/07420528.2016.1220386. Epub 
      2016 Sep 9.