PMID- 27612799
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20220318
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 69
DP  - 2016 Dec 1
TI  - Synthesis and evaluation of temperature- and glucose-sensitive nanoparticles 
      based on phenylboronic acid and N-vinylcaprolactam for insulin delivery.
PG  - 1026-35
LID - S0928-4931(16)30752-4 [pii]
LID - 10.1016/j.msec.2016.07.078 [doi]
AB  - Poly N-vinylcaprolactam-co-acrylamidophenylboronic acid p(NVCL-co-AAPBA) was 
      prepared from N-vinylcaprolactam (NVCL) and 3-acrylamidophenylboronic acid 
      (AAPBA), using 2,2-azobisisobutyronitrile (AIBN) as initiator. The synthesis and 
      structure of the polymer were examined by Fourier Transform infrared spectroscopy 
      (FT-IR) and (1)H-NMR. Dynamic light scattering (DLS), lower critical solution 
      temperature (LCST) and transmission electron microscopy (TEM) were utilized to 
      characterize the nanoparticles, CD spectroscopy was used to determine if there 
      were any changes to the conformation of the insulin, and cell and animal toxicity 
      were also investigated. The prepared nanoparticles were found to be monodisperse 
      submicron particles and were glucose- and temperature-sensitive. In addition, the 
      nanoparticles have good insulin-loading characteristics, do not affect the 
      conformation of the insulin and show low-toxicity to cells and animals. These 
      p(NVCL-co-AAPBA) nanoparticles may have some value for insulin or other 
      hypoglycemic protein delivery.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Wu, Jun-Zi
AU  - Wu JZ
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai, 201620, PR China.
FAU - Bremner, David H
AU  - Bremner DH
AD  - School of Science, Engineering and Technology, Kydd Building, Abertay University, 
      Dundee DD1 1HG, Scotland, UK.
FAU - Li, He-Yu
AU  - Li HY
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai, 201620, PR China.
FAU - Sun, Xiao-Zhu
AU  - Sun XZ
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai, 201620, PR China.
FAU - Zhu, Li-Min
AU  - Zhu LM
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai, 201620, PR China. Electronic address: lzhu@dhu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160802
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Blood Glucose)
RN  - 0 (Boronic Acids)
RN  - 0 (Insulin)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 25189-83-7 (poly-N-vinylcaprolactam)
RN  - 6879X594Z8 (Caprolactam)
RN  - IY9XDZ35W2 (Glucose)
RN  - L12H7B02G5 (benzeneboronic acid)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Boronic Acids/*chemistry
MH  - Caprolactam/*analogs & derivatives/chemistry
MH  - Cell Death/drug effects
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Circular Dichroism
MH  - *Drug Delivery Systems
MH  - Female
MH  - Glucose/*analysis
MH  - Humans
MH  - Hydrodynamics
MH  - Hydrogen-Ion Concentration
MH  - Insulin/*administration & dosage/*pharmacology
MH  - Male
MH  - Mice
MH  - Micelles
MH  - Molecular Weight
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Particle Size
MH  - Polymers/*chemistry
MH  - Proton Magnetic Resonance Spectroscopy
MH  - Rats
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Static Electricity
MH  - *Temperature
OTO - NOTNLM
OT  - 3-Acrylamidophenylboronic acid (AAPBA)
OT  - Glucose-sensitive
OT  - N-vinylcaprolactam (NVCL)
OT  - Nanoparticles (NPs)
OT  - Temperature-sensitive
EDAT- 2016/09/11 06:00
MHDA- 2017/04/22 06:00
CRDT- 2016/09/11 06:00
PHST- 2016/04/14 00:00 [received]
PHST- 2016/07/11 00:00 [revised]
PHST- 2016/07/31 00:00 [accepted]
PHST- 2016/09/11 06:00 [entrez]
PHST- 2016/09/11 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
AID - S0928-4931(16)30752-4 [pii]
AID - 10.1016/j.msec.2016.07.078 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:1026-35. doi: 
      10.1016/j.msec.2016.07.078. Epub 2016 Aug 2.