PMID- 27614005
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20231019
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 38
IP  - 1
DP  - 2017 Jan
TI  - Assessing neuronal density in peri-infarct cortex with PET: Effects of cortical 
      topology and partial volume correction.
PG  - 326-338
LID - 10.1002/hbm.23363 [doi]
AB  - The peri-infarct cortex (PIC) is the site of long-term physiologic changes after 
      ischemic stroke. Traditional methods for delineating the peri-infarct gray matter 
      (GM) have used a volumetric Euclidean distance metric to define its extent around 
      the infarct. This metric has limitations in the case of cortical stroke, i.e., 
      those where ischemia leads to infarction in the cortical GM, because the 
      vascularization of the cerebral cortex follows the complex, folded topology of 
      the cortical surface. Instead, we used a geodesic distance metric along the 
      cortical surface to subdivide the PIC into equidistant rings emanating from the 
      infarct border and compared this new approach to a Euclidean distance metric 
      definition. This was done in 11 patients with [F-18]-Flumazenil ([18-F]-FMZ) 
      positron emission tomography (PET) scans at 2 weeks post-stroke and at 6 month 
      follow-up. FMZ is a PET radiotracer with specific binding to the alpha subunits 
      of the type A gamma-aminobutyric acid (GABAA) receptor. Additionally, we used 
      partial-volume correction (PVC) of the PET images to compensate for potential 
      cortical thinning and long-term neuronal loss in follow-up images. The difference 
      in non-displaceable binding potential (BP(ND) ) between the stroke unaffected and 
      affected hemispheres was 35% larger in the geodesic versus the Euclidean 
      peri-infarct models in initial PET images and 48% larger in follow-up PET images. 
      The inter-hemispheric BP(ND) difference was approximately 17-20% larger after PVC 
      when compared to uncorrected PET images. PET studies of peri-infarct GM in 
      cortical strokes should use a geodesic model and include PVC as a preprocessing 
      step. Hum Brain Mapp 38:326-338, 2017. (c) 2016 Wiley Periodicals, Inc.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Funck, Thomas
AU  - Funck T
AD  - Montreal Neurological Institute, McGill University, Montreal, Canada.
AD  - Jewish General Hospital, Lady Davis Institute, Montreal, Canada.
FAU - Al-Kuwaiti, Mohammed
AU  - Al-Kuwaiti M
AD  - Montreal Neurological Institute, McGill University, Montreal, Canada.
AD  - Jewish General Hospital, Lady Davis Institute, Montreal, Canada.
FAU - Lepage, Claude
AU  - Lepage C
AD  - Montreal Neurological Institute, McGill University, Montreal, Canada.
FAU - Zepper, Peter
AU  - Zepper P
AD  - Department of Neurology, Technische Universitat Munchen, Munich, Germany.
FAU - Minuk, Jeffrey
AU  - Minuk J
AD  - Jewish General Hospital, Lady Davis Institute, Montreal, Canada.
FAU - Schipper, Hyman M
AU  - Schipper HM
AD  - Jewish General Hospital, Lady Davis Institute, Montreal, Canada.
FAU - Evans, Alan C
AU  - Evans AC
AD  - Montreal Neurological Institute, McGill University, Montreal, Canada.
FAU - Thiel, Alexander
AU  - Thiel A
AD  - Montreal Neurological Institute, McGill University, Montreal, Canada.
AD  - Jewish General Hospital, Lady Davis Institute, Montreal, Canada.
LA  - eng
GR  - MOP-115107/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160910
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
CIN - Hum Brain Mapp. 2017 Nov;38(11):5822-5824. PMID: 28731596
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Brain Infarction/diagnostic imaging/*etiology/*pathology
MH  - Cerebral Cortex/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/etiology/*pathology
MH  - Neurons/*pathology
MH  - *Positron-Emission Tomography
MH  - Retrospective Studies
MH  - Stroke/complications
PMC - PMC6866936
OTO - NOTNLM
OT  - PET
OT  - ischemic stroke
OT  - neuronal density
OT  - partial-volume effects
OT  - receptor mapping
EDAT- 2016/09/11 06:00
MHDA- 2018/02/13 06:00
PMCR- 2016/09/10
CRDT- 2016/09/11 06:00
PHST- 2015/12/10 00:00 [received]
PHST- 2016/08/05 00:00 [revised]
PHST- 2016/08/18 00:00 [accepted]
PHST- 2016/09/11 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2016/09/11 06:00 [entrez]
PHST- 2016/09/10 00:00 [pmc-release]
AID - HBM23363 [pii]
AID - 10.1002/hbm.23363 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2017 Jan;38(1):326-338. doi: 10.1002/hbm.23363. Epub 2016 Sep 10.