PMID- 27614850
OWN - NLM
STAT- MEDLINE
DCOM- 20170524
LR  - 20180911
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 118
IP  - 7
DP  - 2016 Oct 1
TI  - Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy.
PG  - 1063-8
LID - S0002-9149(16)31191-2 [pii]
LID - 10.1016/j.amjcard.2016.06.059 [doi]
AB  - The purpose of this study was to determine the prognostic value of late 
      gadolinium enhancement seen on cardiac magnetic resonance (CMR) imaging in 
      patients with nonischemic cardiomyopathy (NICMP). Patients with NICMP are at 
      increased risk for cardiovascular events and death. The presence of late 
      gadolinium enhancement (LGE) in CMR may be associated with a poor prognosis, but 
      its significance is still under investigation. We retrospectively studied 105 
      consecutive patients with NICMP and left ventricular ejection fraction (LVEF) 
      </=40% referred for CMR. The cohort was analyzed for the presence of LGE and left 
      and right ventricular functional parameters. Patients were followed for the 
      composite end point of hospitalization for congestive heart failure, appropriate 
      implantable cardioverter-defibrillator therapy, or all-cause mortality. LGE was 
      observed in 68% (n = 71) of the cohort. Both groups were similar in age, LVEF and 
      LV end-diastolic volume. The LGE+ patients were more often men and had larger 
      right ventricular volumes. At a mean follow-up of 806 +/- 582 days, there were 26 
      patients (23 in the LGE+ group) who reached the primary end point. Event-free 
      survival was significantly worse for the LGE+ patients. After adjusting for 
      traditional risk factors (age, gender, and LVEF), patients with LGE had an 
      increased risk of experiencing the primary end point (hazard ratio 4.47, 95% CIs 
      1.27 to 15.74, p = 0.02). The presence of LGE in patients with NICMP strongly 
      predicts the occurrence of adverse events. In conclusion, this may be important 
      in risk stratification and management.
CI  - Copyright (c) 2016. Published by Elsevier Inc.
FAU - Gaztanaga, Juan
AU  - Gaztanaga J
AD  - Department of Medicine, Winthrop University Hospital, Mineola, New York.
FAU - Paruchuri, Vijayapraveena
AU  - Paruchuri V
AD  - Department of Medicine, Winthrop University Hospital, Mineola, New York.
FAU - Elias, Elliott
AU  - Elias E
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York.
FAU - Wilner, Jonathan
AU  - Wilner J
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York.
FAU - Islam, Shahidul
AU  - Islam S
AD  - Department of Medicine, Winthrop University Hospital, Mineola, New York.
FAU - Sawit, Simonette
AU  - Sawit S
AD  - Department of Medicine, The Medical City, Pasig City, Philippines.
FAU - Viles-Gonzalez, Juan
AU  - Viles-Gonzalez J
AD  - Department of Medicine, University of Miami Hospital, Miami, Florida.
FAU - Sanz, Javier
AU  - Sanz J
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York.
FAU - Garcia, Mario J
AU  - Garcia MJ
AD  - Department of Medicine, Montefiore-Einstein Center for Heart and Vascular Care, 
      Albert Einstein College of Medicine, Bronx, New York. Electronic address: 
      mariogar@montefiore.org.
LA  - eng
PT  - Journal Article
DEP - 20160718
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathies/*diagnostic imaging/epidemiology
MH  - Cohort Studies
MH  - Contrast Media
MH  - Defibrillators, Implantable
MH  - Female
MH  - Gadolinium DTPA
MH  - Heart Failure/epidemiology
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Tachycardia, Ventricular/epidemiology
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/epidemiology
MH  - Ventricular Dysfunction, Right/*diagnostic imaging/epidemiology
MH  - Ventricular Fibrillation/epidemiology
EDAT- 2016/09/12 06:00
MHDA- 2017/05/26 06:00
CRDT- 2016/09/12 06:00
PHST- 2016/02/09 00:00 [received]
PHST- 2016/06/30 00:00 [revised]
PHST- 2016/06/30 00:00 [accepted]
PHST- 2016/09/12 06:00 [entrez]
PHST- 2016/09/12 06:00 [pubmed]
PHST- 2017/05/26 06:00 [medline]
AID - S0002-9149(16)31191-2 [pii]
AID - 10.1016/j.amjcard.2016.06.059 [doi]
PST - ppublish
SO  - Am J Cardiol. 2016 Oct 1;118(7):1063-8. doi: 10.1016/j.amjcard.2016.06.059. Epub 
      2016 Jul 18.