PMID- 27617353
OWN - NLM
STAT- MEDLINE
DCOM- 20170412
LR  - 20170412
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 64
IP  - 40
DP  - 2016 Oct 12
TI  - Metabolism and Residues of 2,4-Dichlorophenoxyacetic Acid in DAS-40278-9 Maize 
      (Zea mays) Transformed with Aryloxyalkanoate Dioxygenase-1 Gene.
PG  - 7438-7444
AB  - DAS-40278-9 maize, which is developed by Dow AgroSciences, has been genetically 
      modified to express the aryloxyalkanoate dioxygenase-1 (AAD-1) protein and is 
      tolerant to phenoxy auxin herbicides, such as 2,4-dichlorophenoxyacetic acid 
      (2,4-D). To understand the metabolic route and residue distribution of 2,4-D in 
      DAS-40278-9 maize, a metabolism study was conducted with (14)C-radiolabeled 2,4-D 
      applied at the maximum seasonal rate. Plants were grown in boxes outdoors. Forage 
      and mature grain, cobs, and stover were collected for analysis. The metabolism 
      study showed that 2,4-D was metabolized to 2,4-dichlorophenol (2,4-DCP), which 
      was then rapidly conjugated with glucose. Field-scale residue studies with 2,4-D 
      applied at the maximum seasonal rate were conducted at 25 sites in the U.S. and 
      Canada to measure the residues of 2,4-D and free and conjugated 2,4-DCP in mature 
      forage, grain, and stover. Residues of 2,4-D were not detectable in the majority 
      of the grain samples and averaged <1.0 and <1.5 mug/g in forage and stover, 
      respectively. Free plus conjugated 2,4-DCP was not observed in grain and averaged 
      <1.0 mug/g in forage and stover.
FAU - Zhou, Xiao
AU  - Zhou X
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Rotondaro, Sandra L
AU  - Rotondaro SL
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Ma, Mingming
AU  - Ma M
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Rosser, Steve W
AU  - Rosser SW
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Olberding, Ed L
AU  - Olberding EL
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Wendelburg, Brian M
AU  - Wendelburg BM
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Adelfinskaya, Yelena A
AU  - Adelfinskaya YA
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Balcer, Jesse L
AU  - Balcer JL
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Blewett, T Craig
AU  - Blewett TC
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
FAU - Clements, Bruce
AU  - Clements B
AD  - Dow AgroSciences, LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United 
      States.
LA  - eng
PT  - Journal Article
DEP - 20160927
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Chlorophenols)
RN  - 0 (Herbicides)
RN  - 0 (Pesticide Residues)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - EC 1.13.11.- (Dioxygenases)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/metabolism/*pharmacokinetics
MH  - Canada
MH  - Chlorophenols/metabolism/pharmacokinetics
MH  - Dioxygenases/*genetics
MH  - Herbicides/metabolism/*pharmacokinetics
MH  - Limit of Detection
MH  - Pesticide Residues/metabolism/pharmacokinetics
MH  - Plants, Genetically Modified/metabolism
MH  - Seasons
MH  - United States
MH  - Zea mays/*drug effects/*genetics/metabolism
OTO - NOTNLM
OT  - 2,4-D
OT  - AAD-1
OT  - DAS-40278-9
OT  - Zea mays
OT  - corn
OT  - metabolism
OT  - residues
OT  - transgenic
EDAT- 2016/09/13 06:00
MHDA- 2017/04/13 06:00
CRDT- 2016/09/13 06:00
PHST- 2016/09/13 06:00 [pubmed]
PHST- 2017/04/13 06:00 [medline]
PHST- 2016/09/13 06:00 [entrez]
AID - 10.1021/acs.jafc.6b03104 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2016 Oct 12;64(40):7438-7444. doi: 10.1021/acs.jafc.6b03104. 
      Epub 2016 Sep 27.