PMID- 27619741
OWN - NLM
STAT- MEDLINE
DCOM- 20170317
LR  - 20171116
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 163
DP  - 2016 Oct
TI  - Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, 
      characterization, cytotoxicity, protein and DNA-binding properties.
PG  - 403-12
LID - S1011-1344(16)30623-6 [pii]
LID - 10.1016/j.jphotobiol.2016.09.005 [doi]
AB  - A series of novel copper (II) and nickel (II) complexes derived from chiral 
      Schiff-base ligands 
      [(R)/(S)-H2L(1)=(R)/(S)-2-[(1-Hydroxymethyl-propylimino)-methyl]-5-methoxy-phenol 
      and 
      (R)/(S)-H2L(2)=(R)/(S)-2-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-5-methoxy-phenol], 
      were synthesized and characterized by elemental analyses, (1)H NMR spectra, FT-IR 
      spectrum. The crystal structures of complexes 1-5 were determined through single 
      crystal X-ray diffraction (SXRD). The structures showed the ligands coordinated 
      to the Cu/Ni (II) ion in a neutral manner via ONO donor atoms, and oxygen atoms 
      of solvent molecules occupy the axial positions in Ni (II) complexes 3 and 4. The 
      complexes interactions with BSA and CT-DNA were investigated by various 
      spectroscopic methods (UV-Visible, circular dichroism spectrum, fluorescence 
      spectroscopic and synchronous fluorescence spectra). Interactions of chiral 
      copper (II) complexes are stronger than nickel (II) complexes. Further, the 
      cytotoxicities of the complexes 1-6 towards three kinds of cancerous cell lines, 
      were human lung adenocarcinoma (A549), human cervical carcinoma cell (HeLa) and 
      human breast cancer cell (MCF-7) respectively, were evaluated by MTT assay. All 
      complexes exhibited good cytotoxic activity. Furthermore, Cu (II) complex 5 
      derived from (R)-Schiff-base ligand was found to be more effective towards HeLa 
      cancerous cell. The results showed that chirality and metal ion have important 
      influence on their anticancer activities and interactions with DNA/BSA.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Li, Zhen
AU  - Li Z
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China.
FAU - Yan, Hui
AU  - Yan H
AD  - College of Pharmacy, Liaocheng University, Liaocheng, Shandong 252059, China.
FAU - Chang, Guoliang
AU  - Chang G
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China.
FAU - Hong, Min
AU  - Hong M
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China.
FAU - Dou, Jianmin
AU  - Dou J
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China.
FAU - Niu, Meiju
AU  - Niu M
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China. Electronic address: niumeiju@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160905
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Ligands)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Schiff Bases)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 789U1901C5 (Copper)
RN  - 7OV03QG267 (Nickel)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antineoplastic Agents/chemical synthesis/chemistry/metabolism/pharmacology
MH  - Chemistry Techniques, Synthetic
MH  - Copper/*chemistry
MH  - DNA/*metabolism
MH  - HeLa Cells
MH  - Humans
MH  - Intracellular Space/drug effects/metabolism
MH  - Ligands
MH  - Molecular Docking Simulation
MH  - Nickel/*chemistry
MH  - Organometallic Compounds/*chemical synthesis/chemistry/metabolism/*pharmacology
MH  - Protein Conformation
MH  - Reactive Oxygen Species/metabolism
MH  - Schiff Bases/chemistry
MH  - Serum Albumin, Bovine/chemistry/*metabolism
MH  - Stereoisomerism
OTO - NOTNLM
OT  - BSA/DNA-binding
OT  - Chiral Schiff-base
OT  - Cytotoxicity
OT  - Metal complex
EDAT- 2016/09/14 06:00
MHDA- 2017/03/18 06:00
CRDT- 2016/09/14 06:00
PHST- 2016/07/30 00:00 [received]
PHST- 2016/09/03 00:00 [accepted]
PHST- 2016/09/14 06:00 [entrez]
PHST- 2016/09/14 06:00 [pubmed]
PHST- 2017/03/18 06:00 [medline]
AID - S1011-1344(16)30623-6 [pii]
AID - 10.1016/j.jphotobiol.2016.09.005 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2016 Oct;163:403-12. doi: 
      10.1016/j.jphotobiol.2016.09.005. Epub 2016 Sep 5.