PMID- 27621357
OWN - NLM
STAT- MEDLINE
DCOM- 20170509
LR  - 20181202
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Print)
IS  - 1941-9651 (Linking)
VI  - 9
IP  - 9
DP  - 2016 Sep
TI  - Presence of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Among 
      Patients With Suspected Cardiac Sarcoidosis Is Associated With Adverse 
      Cardiovascular Prognosis: A Systematic Review and Meta-Analysis.
PG  - e005001
LID - 10.1161/CIRCIMAGING.116.005001 [doi]
AB  - BACKGROUND: Individuals with cardiac sarcoidosis have an increased risk of 
      ventricular arrhythmia and death. Several small cohort studies have evaluated the 
      ability of late gadolinium enhancement (LGE) by cardiac magnetic resonance 
      imaging (MRI) to predict adverse cardiovascular events. However, studies have 
      yielded inconsistent results, and some analyses were underpowered. Therefore, we 
      sought to systematically review and perform meta-analysis of the prognostic value 
      of cardiac MRI for patients with known or suspected cardiac sarcoidosis. METHODS 
      AND RESULTS: We systematically searched for cohort studies of patients with known 
      sarcoidosis with suspected cardiac involvement who underwent cardiac MRI with LGE 
      with at least 12 months of either prospective or retrospective follow-up data 
      regarding post-MRI adverse cardiovascular outcomes. We identified 7 studies of 
      694 subjects (mean age 53; 42% men).One hundred and ninety-nine patients (29%) 
      were LGE positive. All-cause mortality occurred in 19 LGE-positive versus 17 
      LGE-negative subjects (annualized incidence, 3.1% versus 0.6%). The pooled 
      relative risk was 3.38 (95% confidence interval, 1.07-10.7; P=0.04). 
      Cardiovascular mortality occurred in 10 LGE-positive versus 2 LGE-negative 
      subjects (annualized incidence, 1.9% versus 0.3%; relative risk 10.7 [95% 
      confidence interval, 1.34-86.3]; P=0.03). Ventricular arrhythmia occurred in 41 
      LGE-positive versus 0 LGE-negative subjects (annualized incidence, 5.9% versus 
      0%; relative risk 19.5 [95% confidence interval, 2.68-143]; P=0.003). A combined 
      end point of death or ventricular arrhythmia occurred in 64 LGE-positive versus 
      18 LGE-negative subjects (annualized incidence, 8.8% versus 0.6%; relative risk 
      6.20 [95% confidence interval, 2.47-15.6]; P<0.001). There was no significant 
      heterogeneity for any outcomes. CONCLUSIONS: LGE is associated with future 
      cardiovascular death and ventricular arrhythmia among patients referred to MRI 
      for known or suspected cardiac sarcoidosis.
CI  - (c) 2016 American Heart Association, Inc.
FAU - Hulten, Edward
AU  - Hulten E
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Agarwal, Vikram
AU  - Agarwal V
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Cahill, Michael
AU  - Cahill M
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Cole, Geoff
AU  - Cole G
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Vita, Tomas
AU  - Vita T
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Parrish, Scott
AU  - Parrish S
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Bittencourt, Marcio Sommer
AU  - Bittencourt MS
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Murthy, Venkatesh L
AU  - Murthy VL
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Kwong, Raymond
AU  - Kwong R
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Di Carli, Marcelo F
AU  - Di Carli MF
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.).
FAU - Blankstein, Ron
AU  - Blankstein R
AD  - From the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and 
      Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) 
      and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National 
      Military Medical Center and Uniformed Services University of Health Sciences, 
      Bethesda, MD; Center for Clinical and Epidemiological Research, University 
      Hospital and Sao Paulo State Cancer Institute-University of Sao Paulo, Brazil 
      (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, Sao 
      Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal 
      Medicine, Division of Cardiovascular Medicine and Department of Radiology, 
      Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, 
      Ann Arbor (V.L.M.). rblankstein@partners.org.
LA  - eng
GR  - T32 HL094301/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Circ Cardiovasc Imaging. 2016 Sep;9(9):e005518. PMID: 27621358
MH  - Arrhythmias, Cardiac/etiology/mortality
MH  - Cardiomyopathies/*diagnostic imaging/mortality/pathology/physiopathology
MH  - Chi-Square Distribution
MH  - Contrast Media/*administration & dosage
MH  - Death, Sudden, Cardiac/etiology
MH  - Disease Progression
MH  - Female
MH  - Gadolinium/*administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Factors
MH  - Sarcoidosis/*diagnostic imaging/mortality/pathology/physiopathology
MH  - *Ventricular Function
PMC - PMC5449111
MID - NIHMS855985
OTO - NOTNLM
OT  - cardiac arrhythmia
OT  - cardiomyopathies
OT  - heart conduction system
OT  - magnetic resonance imaging
OT  - sarcoidosis
EDAT- 2016/09/14 06:00
MHDA- 2017/05/10 06:00
PMCR- 2017/05/30
CRDT- 2016/09/14 06:00
PHST- 2016/04/12 00:00 [received]
PHST- 2016/08/05 00:00 [accepted]
PHST- 2016/09/14 06:00 [entrez]
PHST- 2016/09/14 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
PHST- 2017/05/30 00:00 [pmc-release]
AID - CIRCIMAGING.116.005001 [pii]
AID - 10.1161/CIRCIMAGING.116.005001 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2016 Sep;9(9):e005001. doi: 
      10.1161/CIRCIMAGING.116.005001.