PMID- 27622136
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20181113
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 12
DP  - 2016
TI  - Amplitude variability over trials in hemodynamic responses in adolescents with 
      ADHD: The role of the anterior default mode network and the non-specific role of 
      the striatum.
PG  - 397-404
LID - 10.1016/j.nicl.2016.08.007 [doi]
AB  - It has been suggested that intra-individual variability (IIV) in performance on 
      attention and other cognitive tasks might be a cognitive endophenotype in 
      individuals with ADHD. Despite robust IIV findings in behavioral data, only 
      sparse data exist on how what type of brain dysfunction underlies variable 
      response times. In this study, we asked whether ADHD IIV in reaction time on a 
      commonly-used test of attention might be related to variation in hemodynamic 
      responses (HRs) observed trial-to-trial. Based on previous studies linking IIV to 
      regions within the "default mode" network (DMN), we predicted that adolescents 
      with ADHD would have higher HR variability in the DMN compared with controls, and 
      this in turn would be related to behavioral IIV. We also explored the influence 
      of social anxiety on HR variability in ADHD as means to test whether higher 
      arousal associated with high trait anxiety would affect the neural abnormalities. 
      We assessed single-trial variability of HRs, estimated from fMRI event-related 
      responses elicited during an auditory oddball paradigm in adolescents with ADHD 
      and healthy controls (11-18 years old; N = 46). Adolescents with ADHD had higher 
      HR variability compared with controls in anterior regions of the DMN. This effect 
      was specific to ADHD and not associated with traits of age, IQ and anxiety. 
      However, an ADHD effect of higher HR variability also appeared in a basal ganglia 
      network, but for these brain regions the relationships of HR variability and 
      social anxiety levels were more complex. Performance IIV correlated significantly 
      with variability of HRs in both networks. These results suggest that assessment 
      of trial-to-trial HR variability in ADHD provides information beyond that 
      detectable through analysis of behavioral data and average brain activation 
      levels, revealing specific neural correlates of a possible ADHD IIV 
      endophenotype.
FAU - Sorensen, L
AU  - Sorensen L
AD  - Department of Biological and Medical Psychology, University of Bergen, Norway; 
      Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; K. G. 
      Jebsen Centre for Neuropsychiatric Disorders, Bergen, Norway.
FAU - Eichele, T
AU  - Eichele T
AD  - Department of Biological and Medical Psychology, University of Bergen, Norway; K. 
      G. Jebsen Centre for Neuropsychiatric Disorders, Bergen, Norway; Section for 
      Clinical Neurophysiology, Department of Neurology, Haukeland University Hospital, 
      Norway; The MIND Research Network, Albuquerque, NM, United States.
FAU - van Wageningen, H
AU  - van Wageningen H
AD  - Department of Biological and Medical Psychology, University of Bergen, Norway; K. 
      G. Jebsen Centre for Neuropsychiatric Disorders, Bergen, Norway.
FAU - Plessen, K J
AU  - Plessen KJ
AD  - K. G. Jebsen Centre for Neuropsychiatric Disorders, Bergen, Norway; Child and 
      Adolescent Mental Health Centre, Capital Region, Copenhagen, Denmark; Department 
      of Clinical Medicine, University of Copenhagen, Denmark.
FAU - Stevens, M C
AU  - Stevens MC
AD  - Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, United 
      States; Department of Psychiatry, Yale University School of Medicine, New Haven, 
      CT, United States.
LA  - eng
GR  - K23 MH070036/MH/NIMH NIH HHS/United States
GR  - R01 MH080956/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160808
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Attention Deficit Disorder with Hyperactivity/complications/*diagnostic 
      imaging/pathology
MH  - Brain/*diagnostic imaging
MH  - *Brain Mapping
MH  - Child
MH  - Corpus Striatum/*diagnostic imaging
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Models, Neurological
MH  - Multivariate Analysis
MH  - Oxygen/blood
MH  - Psychiatric Status Rating Scales
PMC - PMC5008047
OTO - NOTNLM
OT  - ADHD
OT  - Anxiety
OT  - Intraindividual variability
OT  - Reaction time
OT  - Single-trial variability
OT  - fMRI
EDAT- 2016/09/14 06:00
MHDA- 2017/11/03 06:00
PMCR- 2016/08/08
CRDT- 2016/09/14 06:00
PHST- 2016/03/07 00:00 [received]
PHST- 2016/08/05 00:00 [revised]
PHST- 2016/08/07 00:00 [accepted]
PHST- 2016/09/14 06:00 [entrez]
PHST- 2016/09/14 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2016/08/08 00:00 [pmc-release]
AID - S2213-1582(16)30144-9 [pii]
AID - 10.1016/j.nicl.2016.08.007 [doi]
PST - epublish
SO  - Neuroimage Clin. 2016 Aug 8;12:397-404. doi: 10.1016/j.nicl.2016.08.007. 
      eCollection 2016.