PMID- 27622870
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Sep 13
TI  - Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes 
      Mellitus With and Without Cognitive Impairment.
PG  - 32980
LID - 10.1038/srep32980 [doi]
LID - 32980
AB  - Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We 
      investigated whether alterations of intranetwork and internetwork functional 
      connectivity with T2DM progression exist, by using resting-state functional MRI. 
      MRI data were analysed from 19 T2DM patients with normal cognition (DMCN) and 19 
      T2DM patients with cognitive impairment (DMCI), 19 healthy controls (HC). 
      Functional connectivity among 36 previously well-defined brain regions which 
      consisted of 5 resting-state network (RSN) systems [default mode network (DMN), 
      dorsal attention network (DAN), control network (CON), salience network (SAL) and 
      sensorimotor network (SMN)] was investigated at 3 levels (integrity, network and 
      connectivity). Impaired intranetwork and internetwork connectivity were found in 
      T2DM, especially in DMCI, on the basis of the three levels of analysis. The 
      bilateral posterior cerebellum, the right insula, the DMN and the CON were mainly 
      involved in these changes. The functional connectivity strength of specific brain 
      architectures in T2DM was found to be associated with haemoglobin A1c (HbA1c), 
      cognitive score and illness duration. These network alterations in intergroup 
      differences, which were associated with brain functional impairment due to T2DM, 
      indicate that network organizations might be potential biomarkers for predicting 
      the clinical progression, evaluating the cognitive impairment, and further 
      understanding the pathophysiology of T2DM.
FAU - Yang, Shi-Qi
AU  - Yang SQ
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Xu, Zhi-Peng
AU  - Xu ZP
AD  - Department of Pathophysiology, School of Basic Medicine and the Collaborative 
      Innovation Center for Brain Science, Key Laboratory of Neurological Diseases of 
      Education Ministry of China, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, Hubei, 430030, China.
AD  - Department of Neurology, Wuhan General Hospital of Guangzhou Command, Wuhan, 
      Hubei, 430070, China.
FAU - Xiong, Ying
AU  - Xiong Y
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Zhan, Ya-Feng
AU  - Zhan YF
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, 
      Guangdong, 510515, China.
AD  - Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 
      Beijing, 100190, China.
FAU - Guo, Lin-Ying
AU  - Guo LY
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Zhang, Shun
AU  - Zhang S
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Jiang, Ri-Feng
AU  - Jiang RF
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Yao, Yi-Hao
AU  - Yao YH
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Qin, Yuan-Yuan
AU  - Qin YY
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Wang, Jian-Zhi
AU  - Wang JZ
AD  - Department of Pathophysiology, School of Basic Medicine and the Collaborative 
      Innovation Center for Brain Science, Key Laboratory of Neurological Diseases of 
      Education Ministry of China, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 
      Beijing, 100190, China.
AD  - National Laboratory of Pattern Recognition, Institute of Automation, Chinese 
      Academy of Sciences, Beijing, 100190, China.
FAU - Zhu, Wen-Zhen
AU  - Zhu WZ
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160913
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/*complications/*diagnostic imaging/physiopathology
MH  - Connectome
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications/*diagnostic imaging/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
PMC - PMC5020685
EDAT- 2016/09/14 06:00
MHDA- 2018/06/05 06:00
PMCR- 2016/09/13
CRDT- 2016/09/14 06:00
PHST- 2015/12/10 00:00 [received]
PHST- 2016/08/16 00:00 [accepted]
PHST- 2016/09/14 06:00 [entrez]
PHST- 2016/09/14 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2016/09/13 00:00 [pmc-release]
AID - srep32980 [pii]
AID - 10.1038/srep32980 [doi]
PST - epublish
SO  - Sci Rep. 2016 Sep 13;6:32980. doi: 10.1038/srep32980.