PMID- 27624606
OWN - NLM
STAT- MEDLINE
DCOM- 20170213
LR  - 20181113
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 11
IP  - 1
DP  - 2016 Sep 13
TI  - Clinicopathological features of idiopathic membranous nephropathy combined with 
      IgA nephropathy: a retrospective analysis of 9 cases.
PG  - 86
LID - 10.1186/s13000-016-0538-7 [doi]
LID - 86
AB  - BACKGROUND: The concomitant presence of idiopathic membranous nephropathy and IgA 
      nephropathy is rare. Here, we report 9 cases of phospholipase-A2-receptor (PLA2R) 
      positive idiopathic membranous nephritis combined with IgA nephropathy, while 
      reviewing publications regarding the pathological characteristics of this 
      glomerolonephritis complication. CASE PRESENTATION: Nine cases of renal biopsy 
      tissues were retrospectively reviewed, including the clinicopathological 
      features, the results of the immunofluorescence assays, and the electron 
      microscopic examination. The patients mainly presented proteinuria and 
      microscopic hematuria, and the serum anti-PLA2R was detected as positive in all 
      of the patients. Histologically, a wide thickening of the glomerular basement 
      membrane was observed in each of the 9 cases. Additionally, there existed mild 
      hyperplasia in the mesangial cell and the matrix of the mesangial area. 
      Immunofluorescence assays showed prominent glomerular granular staining on the 
      glomerular capillary loops for IgG (++/+++), IgG4 (++/++++), and PLA2R (+/++). In 
      addition, moderate IgA positive stains were focally or sparsely limited to the 
      mesangial areas. Electron microscopy revealed subepithelial and mesangial 
      electron-dense deposits. CONCLUSIONS: The results from the case analyses 
      indicated that idiopathic membranous nephropathy combined with IgA nephropathy 
      possess the clinicopathological features found in both components. It is 
      suggested that serum anti-PLA2R and tissue PLA2R are important biomarkers that 
      can assist in the diagnosis of idiopathic membranous nephropathy associated with 
      IgA nephropathy.
FAU - Hu, Ruimin
AU  - Hu R
AD  - Department of Pathology, School of Basic Medical Sciences, Fudan University, 138, 
      Yixueyuan Road, Xuhui District, Shanghai, 200032, People's Republic of China.
AD  - Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 
      1, Jianshe Road East, Erqi District, Zhengzhou, Henan, 450052, People's Republic 
      of China.
FAU - Xing, Guolan
AU  - Xing G
AD  - Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 
      1, Jianshe Road East, Erqi District, Zhengzhou, Henan, 450052, People's Republic 
      of China. xgl@zzu.edu.cn.
FAU - Wu, Huijuan
AU  - Wu H
AD  - Department of Pathology, School of Basic Medical Sciences, Fudan University, 138, 
      Yixueyuan Road, Xuhui District, Shanghai, 200032, People's Republic of China.
FAU - Zhang, Zhigang
AU  - Zhang Z
AUID- ORCID: 0000-0001-7895-9332
AD  - Department of Pathology, School of Basic Medical Sciences, Fudan University, 138, 
      Yixueyuan Road, Xuhui District, Shanghai, 200032, People's Republic of China. 
      zzg@shmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160913
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (PLA2R1 protein, human)
RN  - 0 (Receptors, Phospholipase A2)
SB  - IM
MH  - Adult
MH  - Autoantibodies/blood
MH  - Biopsy
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Glomerulonephritis, IGA/*complications/immunology/pathology
MH  - Glomerulonephritis, Membranous/*complications/immunology/pathology
MH  - Humans
MH  - Immunoglobulin A/*analysis
MH  - Immunoglobulin G/analysis
MH  - Kidney/*immunology/ultrastructure
MH  - Male
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Receptors, Phospholipase A2/*immunology
MH  - Retrospective Studies
PMC - PMC5022150
OTO - NOTNLM
OT  - Idiopathic membranous nephropathy
OT  - IgA nephropathy
OT  - PLA2R
EDAT- 2016/09/15 06:00
MHDA- 2017/02/14 06:00
PMCR- 2016/09/13
CRDT- 2016/09/15 06:00
PHST- 2016/04/19 00:00 [received]
PHST- 2016/09/02 00:00 [accepted]
PHST- 2016/09/15 06:00 [entrez]
PHST- 2016/09/15 06:00 [pubmed]
PHST- 2017/02/14 06:00 [medline]
PHST- 2016/09/13 00:00 [pmc-release]
AID - 10.1186/s13000-016-0538-7 [pii]
AID - 538 [pii]
AID - 10.1186/s13000-016-0538-7 [doi]
PST - epublish
SO  - Diagn Pathol. 2016 Sep 13;11(1):86. doi: 10.1186/s13000-016-0538-7.