PMID- 27625341
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20221207
IS  - 2048-8734 (Electronic)
IS  - 2048-8726 (Linking)
VI  - 6
IP  - 8
DP  - 2017 Dec
TI  - Editor's Choice- Diagnosis of type 2 diabetes and prediabetes among patients with 
      acute coronary syndromes.
PG  - 744-749
LID - 10.1177/2048872616669060 [doi]
AB  - BACKGROUND: Previously undetected dysglycaemia is common among patients with 
      acute coronary syndromes (ACSs). The aim of this study was to identify the most 
      reliable method of diagnosing type 2 diabetes mellitus (T2DM) and prediabetes in 
      ACS patients. METHODS: Patients admitted to the coronary care unit with ACSs and 
      no previous history of T2DM were consecutively included in the study. Glucose 
      metabolism was measured by glycated haemoglobin (HbA1c), fasting plasma glucose 
      (FPG) and 2-hour plasma glucose (2hPG) with a standard oral glucose tolerance 
      test during hospital admission, and this process was repeated 3 months later. In 
      this study, the diagnosis of T2DM required at least two measurements above the 
      diabetes cut-off point according to current American Diabetes Association and 
      World Health Organization criteria. RESULTS: A total of 250 patients were 
      included in the study. T2DM was diagnosed in 7.2%. The sensitivities for 
      detecting T2DM were 33.3%, 61.1% and 77.8% during admission and 27.8%, 61.1% and 
      72.2% at follow-up for HbA1c, FPG and 2hPG, respectively. The positive predictive 
      values (PPVs) for diagnosing T2DM were 100%, 91.7% and 51.9% during admission and 
      71.4%, 91.7% and 65.0% at follow-up for HbA1c, FPG and 2hPG, respectively. The 
      specificities and negative predictive values were high for all methods. By 
      combining all measurements, the sensitivity was 100% and the PPV was 44.2%, while 
      the combination of all HbA1c and FPG measurements provided 88.9% sensitivity and 
      80.0% PPV. CONCLUSION: Diagnosis of T2DM can be reliably carried out by repeated 
      measurements of FPG and HbA1c in ACS patients, with limited added value of an 
      oral glucose tolerance test.
FAU - Bjarnason, Thorarinn A
AU  - Bjarnason TA
AD  - 1 Department of Medicine, Division of Cardiology, Landspitali the National 
      University Hospital of Iceland, Reykjavik, Iceland.
AD  - 2 University of Iceland, School of Health Sciences, Reykjavik, Iceland.
FAU - Kristinsdottir, Linda B
AU  - Kristinsdottir LB
AD  - 2 University of Iceland, School of Health Sciences, Reykjavik, Iceland.
FAU - Oskarsdottir, Erna S
AU  - Oskarsdottir ES
AD  - 2 University of Iceland, School of Health Sciences, Reykjavik, Iceland.
FAU - Hafthorsson, Steinar O
AU  - Hafthorsson SO
AD  - 2 University of Iceland, School of Health Sciences, Reykjavik, Iceland.
FAU - Olafsson, Isleifur
AU  - Olafsson I
AD  - 3 Department of Clinical Biochemistry, Landspitali the National University 
      Hospital of Iceland, Reykjavik, Iceland.
FAU - Lund, Sigrun H
AU  - Lund SH
AD  - 2 University of Iceland, School of Health Sciences, Reykjavik, Iceland.
FAU - Andersen, Karl
AU  - Andersen K
AD  - 1 Department of Medicine, Division of Cardiology, Landspitali the National 
      University Hospital of Iceland, Reykjavik, Iceland.
AD  - 2 University of Iceland, School of Health Sciences, Reykjavik, Iceland.
LA  - eng
PT  - Journal Article
DEP - 20160913
PL  - England
TA  - Eur Heart J Acute Cardiovasc Care
JT  - European heart journal. Acute cardiovascular care
JID - 101591369
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Acute Coronary Syndrome/*complications/diagnosis/mortality
MH  - Blood Glucose/*metabolism
MH  - Coronary Care Units
MH  - Diabetes Mellitus, Type 2/complications/*diagnosis/epidemiology
MH  - Electrocardiography
MH  - Female
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Iceland/epidemiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/complications/*diagnosis/epidemiology
MH  - Prognosis
MH  - ROC Curve
MH  - Survival Rate
OTO - NOTNLM
OT  - Type 2 diabetes
OT  - acute coronary syndrome
OT  - cardiovascular disease(s)
OT  - diagnosis
OT  - prediabetes
EDAT- 2016/09/15 06:00
MHDA- 2018/07/22 06:00
CRDT- 2016/09/15 06:00
PHST- 2016/09/15 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2016/09/15 06:00 [entrez]
AID - 2048872616669060 [pii]
AID - 10.1177/2048872616669060 [doi]
PST - ppublish
SO  - Eur Heart J Acute Cardiovasc Care. 2017 Dec;6(8):744-749. doi: 
      10.1177/2048872616669060. Epub 2016 Sep 13.