PMID- 27627895
OWN - NLM
STAT- MEDLINE
DCOM- 20170308
LR  - 20181202
IS  - 1573-6776 (Electronic)
IS  - 0141-5492 (Linking)
VI  - 39
IP  - 1
DP  - 2017 Jan
TI  - Promigratory and proangiogenic effects of AdipoRon on bone marrow-derived 
      mesenchymal stem cells: an in vitro study.
PG  - 39-44
LID - 10.1007/s10529-016-2214-0 [doi]
AB  - OBJECTIVES: To investigate the effect of AdipoRon on major factors involved in 
      survival, migration and neovascularization of rat bone marrow-derived mesenchymal 
      stem cells. RESULTS: AdipoRon promoted the MSCs viability. Real-time PCR 
      indicated that the expression of cyclooxygenase-2 (COX-2), hypoxia-inducible 
      factor-1 (HIF-1) C-X-C chemokine receptor type 4 (CXCR4), C-C chemokine receptor 
      type 2 (CCR2), vascular endothelial growth factor matrix metalloproteinase-2 
      (MMP-2) and MMP-9 were upregulated in AdipoRon-treated MSCs compared to control 
      groups. Prostaglandin E2 (PGE2) level, as well as migration ability of MSCs 
      (scratch assay) was enhanced by AdipoRon preconditioning. CONCLUSION: 
      Preconditioning of MSCs with AdipoRon prior to transplantation could enhance cell 
      survival, angiogenesis and migration via activating the COX-2/PGE2/HIF-1 pathway 
      and other contributing factors.
FAU - Malih, Sara
AU  - Malih S
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Saidijam, Massoud
AU  - Saidijam M
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Mansouri, Kamran
AU  - Mansouri K
AD  - Medical Biology Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Pourjafar, Mona
AU  - Pourjafar M
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Tafakh, Maryam Sadat
AU  - Tafakh MS
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Talebzadeh, Fahimeh
AU  - Talebzadeh F
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Najafi, Rezvan
AU  - Najafi R
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran. re.najafi@umsha.ac.ir.
AD  - Endometrium and Endometriosis Research Center, Hamadan University of Medical 
      Sciences, Hamadan, Iran. re.najafi@umsha.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20160915
PL  - Netherlands
TA  - Biotechnol Lett
JT  - Biotechnology letters
JID - 8008051
RN  - 0 (AdipoRon)
RN  - 0 (Ccr2 protein, rat)
RN  - 0 (Cxcr4 protein, rat)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CXCR4)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*cytology
MH  - Cells, Cultured
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Mesenchymal Stem Cells/*cytology/*drug effects/metabolism
MH  - Piperidines/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, CCR2/metabolism
MH  - Receptors, CXCR4/metabolism
OTO - NOTNLM
OT  - AdipoRon
OT  - Adiponectin
OT  - Cyclooxygenase-2
OT  - HIF-1
OT  - Mesenchymal stem cell
OT  - Prostaglandin E2
EDAT- 2016/09/16 06:00
MHDA- 2017/03/09 06:00
CRDT- 2016/09/16 06:00
PHST- 2016/07/29 00:00 [received]
PHST- 2016/09/09 00:00 [accepted]
PHST- 2016/09/16 06:00 [pubmed]
PHST- 2017/03/09 06:00 [medline]
PHST- 2016/09/16 06:00 [entrez]
AID - 10.1007/s10529-016-2214-0 [pii]
AID - 10.1007/s10529-016-2214-0 [doi]
PST - ppublish
SO  - Biotechnol Lett. 2017 Jan;39(1):39-44. doi: 10.1007/s10529-016-2214-0. Epub 2016 
      Sep 15.