PMID- 2763024
OWN - NLM
STAT- MEDLINE
DCOM- 19890908
LR  - 20131121
IS  - 0039-6060 (Print)
IS  - 0039-6060 (Linking)
VI  - 106
IP  - 2
DP  - 1989 Aug
TI  - Selective effects of tumor necrosis factor-alpha on wound healing in rats.
PG  - 171-5; discussion 175-6
AB  - Many growth factors are believed to act simultaneously in wounds. Tumor necrosis 
      factor-alpha (TNF-alpha) is a cytokine released by activated macrophages. In 
      various concentrations it has inflammatory, cytolytic, mitogenic, antitumor, and 
      possibly angiogenic or antiangiogenic effects; therefore it is likely to affect 
      wound healing. With stainless steel wire mesh wound cylinders implanted in rats, 
      we tested topical TNF-alpha in wounds, alone and in combination with 
      platelet-derived growth factor (PDGF) and transforming growth factor-beta 
      (TGF-beta). The cylinders were injected daily for a total of 12 days, after which 
      we measured the accumulation of protein, DNA, and hydroxyproline in each 
      cylinder. TNF-alpha had little effect by itself; it inhibited the 
      growth-promoting effects of TGF-beta, but it did not influence the effects of 
      PDGF. These results agree with the in vitro studies showing synergism of 
      TNF-alpha and PDGF and antagonism between TGF-beta and TNF-alpha. They also 
      suggest that TGF-beta may have a negligible role in normal healing and emphasize 
      that interaction of growth factors must be understood before appropriate clinical 
      use can be planned.
FAU - Steenfos, H H
AU  - Steenfos HH
AD  - Department of Surgery, University of California, San Francisco 94143-0144.
FAU - Hunt, T K
AU  - Hunt TK
FAU - Scheuenstuhl, H
AU  - Scheuenstuhl H
FAU - Goodson, W H 3rd
AU  - Goodson WH 3rd
LA  - eng
GR  - GM 27345/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-34-5 (Collagen)
RN  - 9007-49-2 (DNA)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Animals
MH  - Cell Division/drug effects
MH  - Collagen/metabolism
MH  - DNA/metabolism
MH  - Hydroxyproline/metabolism
MH  - Male
MH  - Platelet-Derived Growth Factor/pharmacology
MH  - Proteins/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Wound Healing/*drug effects
EDAT- 1989/08/01 00:00
MHDA- 1989/08/01 00:01
CRDT- 1989/08/01 00:00
PHST- 1989/08/01 00:00 [pubmed]
PHST- 1989/08/01 00:01 [medline]
PHST- 1989/08/01 00:00 [entrez]
AID - 0039-6060(89)90205-5 [pii]
PST - ppublish
SO  - Surgery. 1989 Aug;106(2):171-5; discussion 175-6.