PMID- 27631133
OWN - NLM
STAT- MEDLINE
DCOM- 20171205
LR  - 20171213
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 118
DP  - 2016 Nov
TI  - Antibodies directed against annexin A2 and obstetric morbidity.
PG  - 50-53
LID - S0165-0378(16)30087-0 [pii]
LID - 10.1016/j.jri.2016.08.010 [doi]
AB  - Acquired and inherited thrombophilia have both been reported to be associated 
      with an increased risk of obstetric complications in early or later stages of 
      pregnancy. Annexin A2 (ANXA2) is strongly expressed in vascular and placental 
      tissues and plays a crucial role in fibrinolysis. The aim of the present study 
      was to evaluate the prevalence of antibodies directed against ANXA2 in patients 
      with recurrent miscarriage or obstetric complications. Anti-ANXA2 antibodies 
      (aANXA2) were detected by ELISA in the sera from 46 women with obstetric 
      morbidity, mainly recurrent miscarriage. The cut-off value for positivity was 
      defined as 3 standard deviations above the mean optical density (OD) obtained in 
      the sera from 42 female blood donors. The prevalence of aANXA2 in patients and 
      healthy individuals was 15.2% and 2.3%, respectively. A statistically significant 
      difference was observed between the 2 groups in terms of aANXA2 IgG titers 
      (p=0.01). The highest aANXA2 levels were observed in sera from 2 patients with 
      recurrent miscarriage and one patient with preeclampsia. aANXA2 could play a role 
      in thrombotic mechanisms leading to recurrent pregnancy loss and placental 
      vascular disease. Further studies are needed to determine whether ANXA2 is 
      critical for maintenance of placental integrity.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Salle, V
AU  - Salle V
AD  - Department of Internal Medicine, Amiens University Hospital, France; INSERM 
      U1088, Biochemistry Laboratory, Amiens University Hospital, France. Electronic 
      address: salle.valery@chu-amiens.fr.
FAU - Schmidt, J
AU  - Schmidt J
AD  - Department of Internal Medicine, Amiens University Hospital, France.
FAU - Smail, A
AU  - Smail A
AD  - Department of Internal Medicine, Amiens University Hospital, France.
FAU - Maziere, C
AU  - Maziere C
AD  - INSERM U1088, Biochemistry Laboratory, Amiens University Hospital, France.
FAU - Conte, M A
AU  - Conte MA
AD  - INSERM U1088, Biochemistry Laboratory, Amiens University Hospital, France.
FAU - Brule, A
AU  - Brule A
AD  - French Blood Establishment-North of France, France.
FAU - Maziere, J C
AU  - Maziere JC
AD  - INSERM U1088, Biochemistry Laboratory, Amiens University Hospital, France.
FAU - Cadet, E
AU  - Cadet E
AD  - Department of Genetics, Amiens University Hospital, France.
FAU - Herpe, Y E
AU  - Herpe YE
AD  - Biobank of Picardie, Amiens University Hospital, Amiens, France.
FAU - Duhaut, P
AU  - Duhaut P
AD  - Department of Internal Medicine, Amiens University Hospital, France.
LA  - eng
PT  - Journal Article
DEP - 20160830
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (ANXA2 protein, human)
RN  - 0 (Annexin A2)
RN  - 0 (Annexin A5)
RN  - 0 (Antibodies, Antiphospholipid)
RN  - Thrombophilia, hereditary
SB  - IM
MH  - Abortion, Habitual/*epidemiology
MH  - Adolescent
MH  - Adult
MH  - Annexin A2/*immunology
MH  - Annexin A5/immunology
MH  - Antibodies, Antiphospholipid/blood
MH  - Case-Control Studies
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Immunity, Humoral
MH  - Morbidity
MH  - Pregnancy
MH  - Prevalence
MH  - Retrospective Studies
MH  - Stillbirth/*epidemiology
MH  - Thrombophilia/*epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Annexin A2
OT  - Anti-annexin A2 antibodies
OT  - Obstetric morbidity
EDAT- 2016/09/16 06:00
MHDA- 2017/12/06 06:00
CRDT- 2016/09/16 06:00
PHST- 2016/03/31 00:00 [received]
PHST- 2016/08/25 00:00 [revised]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/09/16 06:00 [pubmed]
PHST- 2017/12/06 06:00 [medline]
PHST- 2016/09/16 06:00 [entrez]
AID - S0165-0378(16)30087-0 [pii]
AID - 10.1016/j.jri.2016.08.010 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2016 Nov;118:50-53. doi: 10.1016/j.jri.2016.08.010. Epub 2016 
      Aug 30.