PMID- 27631235
OWN - NLM
STAT- MEDLINE
DCOM- 20170213
LR  - 20240325
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 37
DP  - 2016 Sep
TI  - Different mean thickness implicates involvement of the cortex in migraine.
PG  - e4824
LID - 10.1097/MD.0000000000004824 [doi]
LID - e4824
AB  - The results of neuroimaging studies on migraines have shown that the functions 
      and functional connectivity networks of some brain regions are altered in 
      migraine patients, and different brain structure volumes have also been observed 
      in recent years. However, it is still not known whether the mean thickness of the 
      cortex is different in migraine patients.A total of 48 migraine without aura 
      (MWoA) patients in interictal phase and 48 healthy controls were enrolled in this 
      study. All subjects received neurological and magnetic resonance imaging (MRI) 
      examinations. Automatic segmentation processing of high-resolution MRI structure 
      images was performed using FreeSurfer software.The mean cortical thickness of 
      many brain regions in the frontal lobe, temporal lobe, occipital lobe, parietal 
      lobe, and insula in the migraine patient group was significantly decreased 
      compared with that in the healthy control group. The mean cortical thickness of 
      the insula anterior was positively correlated with the duration of the disease 
      course, while the mean cortical thickness of insula superior and insula inferior 
      was negatively correlated with the duration of the disease course.The results 
      showed that MWoA results from a complex interactive reaction involving many brain 
      regions and many brain network systems together. However, it is still not clear 
      whether the difference in the brain structure of migraine patients is the result 
      or the cause of headache, which is a topic that must be better elucidated. 
      Therefore, longitudinal neuroimaging studies on migraine patients with large 
      samples sizes should be performed using more advanced neuroimaging techniques.
FAU - Yu, Zhi-Bo
AU  - Yu ZB
AD  - Department of Radiology, The First Affiliated Hospital, Third Military Medical 
      University Department of Medical Imaging, PLA No.324 Hospital Department of 
      Neurology, The First Affiliated Hospital, Third Military Medical University 
      Department of General Surgery, PLA No.324 Hospital, Chongqing, China.
FAU - Peng, Jing
AU  - Peng J
FAU - Lv, Yan-Bing
AU  - Lv YB
FAU - Zhao, Ming
AU  - Zhao M
FAU - Xie, Bing
AU  - Xie B
FAU - Liang, Ming-Long
AU  - Liang ML
FAU - Li, Hai-Tao
AU  - Li HT
FAU - Zhou, Zhen-Hua
AU  - Zhou ZH
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Cerebral Cortex/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Migraine without Aura/*diagnostic imaging
MH  - Young Adult
PMC - PMC5402578
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/09/16 06:00
MHDA- 2017/02/14 06:00
PMCR- 2016/09/16
CRDT- 2016/09/16 06:00
PHST- 2016/09/16 06:00 [entrez]
PHST- 2016/09/16 06:00 [pubmed]
PHST- 2017/02/14 06:00 [medline]
PHST- 2016/09/16 00:00 [pmc-release]
AID - 00005792-201609130-00037 [pii]
AID - 10.1097/MD.0000000000004824 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Sep;95(37):e4824. doi: 10.1097/MD.0000000000004824.