PMID- 27631349
OWN - NLM
STAT- MEDLINE
DCOM- 20170420
LR  - 20181113
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Print)
IS  - 0277-3740 (Linking)
VI  - 35 Suppl 1
IP  - Suppl 1
DP  - 2016 Nov
TI  - Novel Insights Into the Immunoregulatory Function and Localization of Dendritic 
      Cells.
PG  - S49-S54
AB  - Dendritic cells (DCs) are antigen-presenting cells that normally play a critical 
      role in stimulating T-cell-dependent immune responses. However, tolerogenic DCs 
      (CD11cMHC-IICD80CD86) induce immune tolerance by stimulating regulatory T cells 
      (Tregs: CD4CD25Foxp3). Although tolerogenic DCs are used to treat autoimmune 
      diseases and to prevent transplantation rejection, the mechanisms by which they 
      regulate alloimmunity are poorly understood. Here, we review our previous studies 
      aiming to elucidate the mechanisms involved in immune rejection of corneal 
      allografts using a corneal transplant model. We found that donor-derived 
      tolerogenic DCs significantly prolonged corneal allograft survival by suppressing 
      indirect allosensitization. We also reported the precise distribution of 
      intraepithelial corneal DCs, termed Langerhans cells (LCs: CD11cLangerinMHC-II) 
      in the cornea, which we maintain play a critical role in regulating corneal 
      immunity. By confocal microscopy, we constructed 3-dimensional images of corneal 
      LCs, which demonstrated that their cell bodies are present in the basal cell 
      layer of the corneal epithelium. Furthermore, LC dendrites extend toward the 
      ocular surface, but do not connect to epithelial tight junctions, indicating that 
      they cannot directly interact with ocular surface antigens. We confirm the 
      potential of DC therapy for corneal graft rejection and report the function of 
      intraepithelial DCs (LCs) in the normal cornea.
FAU - Hattori, Takaaki
AU  - Hattori T
AD  - *Department of Ophthalmology, Toyo Medical University, Tokyo, Japan; and 
      daggerSchepens Eye Research Institute/Massachusetts Eye and Ear Infirmary, Harvard 
      Medical School, Boston, MA.
FAU - Takahashi, Hiroki
AU  - Takahashi H
FAU - Dana, Reza
AU  - Dana R
LA  - eng
GR  - R01 EY012963/EY/NEI NIH HHS/United States
GR  - R01 EY020889/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
SB  - IM
MH  - Allografts
MH  - Animals
MH  - *Corneal Transplantation
MH  - Dendritic Cells/immunology
MH  - Graft Rejection/*immunology
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Immune Tolerance/physiology
MH  - Microscopy, Confocal
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Tissue Donors
PMC - PMC5067968
MID - NIHMS801597
COIS- The authors have no conflicts of interest to declare.
EDAT- 2016/10/18 06:00
MHDA- 2017/04/21 06:00
PMCR- 2017/11/01
CRDT- 2016/09/16 06:00
PHST- 2016/10/18 06:00 [pubmed]
PHST- 2017/04/21 06:00 [medline]
PHST- 2016/09/16 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 10.1097/ICO.0000000000001005 [doi]
PST - ppublish
SO  - Cornea. 2016 Nov;35 Suppl 1(Suppl 1):S49-S54. doi: 10.1097/ICO.0000000000001005.