PMID- 27631478
OWN - NLM
STAT- MEDLINE
DCOM- 20170705
LR  - 20180206
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 47
IP  - 9
DP  - 2016 Sep 1
TI  - In Vivo Evidence of Inner Retinal Neurodegeneration in Retinitis Pigmentosa Using 
      Spectral-Domain Optical Coherence Tomography.
PG  - 828-35
LID - 10.3928/23258160-20160901-05 [doi]
AB  - BACKGROUND AND OBJECTIVE: To investigate the topographic changes in macular 
      ganglion cell inner plexiform layer (GCIPL) thickness in eyes with retinitis 
      pigmentosa (RP). PATIENTS AND METHODS: Forty-five eyes of 25 subjects with RP who 
      underwent spectral-domain optical coherence tomography (SD-OCT) using the Cirrus 
      HD-OCT (Carl Zeiss Meditec, Dublin, CA) were analyzed retrospectively. A control 
      group of 67 eyes of 48 age-matched healthy volunteers was also included for 
      comparison. Average, minimum, and sectoral macular GCIPL, as well as retinal 
      nerve fiber layer (RNFL) and outer retinal (OR) thicknesses, were collected and 
      compared between RP and control groups. RESULTS: The average and sectoral macular 
      GCIPL thicknesses were significantly reduced in RP eyes compared with controls (P 
      < .0001). Average macular RNFL thickness was reduced in RP eyes compared with 
      controls (P < .054). CONCLUSIONS: In eyes with RP, display reduced GCIPL, RNFL, 
      and OR thickness. The identification of alteration in RNFL, OR, and GCIPL 
      thickness may be useful for future therapeutic implications. [Ophthalmic Surg 
      Lasers Imaging Retina. 2016;47:828-835.].
CI  - Copyright 2016, SLACK Incorporated.
FAU - Alshareef, Rayan A
AU  - Alshareef RA
FAU - You, Qisheng
AU  - You Q
FAU - Barteselli, Giulio
AU  - Barteselli G
FAU - Rao, Harsha L
AU  - Rao HL
FAU - Goud, Ashwin
AU  - Goud A
FAU - Chhablani, Jay
AU  - Chhablani J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Degeneration/*diagnosis/etiology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retinal Pigment Epithelium/pathology
MH  - Retinitis Pigmentosa/*complications/diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
EDAT- 2016/09/16 06:00
MHDA- 2017/07/06 06:00
CRDT- 2016/09/16 06:00
PHST- 2016/04/17 00:00 [received]
PHST- 2016/06/23 00:00 [accepted]
PHST- 2016/09/16 06:00 [entrez]
PHST- 2016/09/16 06:00 [pubmed]
PHST- 2017/07/06 06:00 [medline]
AID - 10.3928/23258160-20160901-05 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2016 Sep 1;47(9):828-35. doi: 
      10.3928/23258160-20160901-05.