PMID- 27633173
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20170406
IS  - 1876-2891 (Electronic)
IS  - 1876-2883 (Linking)
VI  - 7
IP  - 5
DP  - 2016 Nov 30
TI  - Citrus juice fermented with Lactobacillus plantarum YIT 0132 alleviates symptoms 
      of perennial allergic rhinitis in a double-blind, placebo-controlled trial.
PG  - 649-658
AB  - This study aimed to examine whether citrus juice fermented with Lactobacillus 
      plantarum YIT 0132 (LP0132), which was pasteurised after fermentation, could 
      alleviate the symptoms of perennial allergic rhinitis in a double-blind, 
      placebo-controlled, parallel-group trial. Subjects with perennial allergic 
      rhinitis consumed LP0132-fermented juice (n=17) or unfermented citrus juice 
      (placebo; n=16) once a day for 8 weeks. During the pre-intervention and 
      intervention periods, the subjects recorded nasal symptoms (number of sneezing 
      attacks, number of nose-blowing incidents, and stuffy nose score). The primary 
      endpoint, nasal symptoms score (NSS), was scored from 0 to 4 according to the 
      'Practical Guideline for the Management of Allergic Rhinitis in Japan 2009' using 
      a combination of the three nasal symptom items. Blood samples were collected at 
      pre-intervention and at 8 weeks after commencing the intervention. There were 
      several significant improvements not only in the LP0132 group but also in the 
      placebo group because of potential anti-allergic effects of citrus. Compared with 
      the placebo group, the LP0132 group showed a significant reduction in the NSS and 
      stuffy nose score during the intervention period. Also, the LP0132 group, but not 
      the placebo group, showed significant attenuation of type 2 helper T cells (Th2 
      cells)/helper T cells, serum total immunoglobulin E (IgE), and eosinophil 
      cationic protein (ECP), and showed significant augmentation of type 1 helper T 
      cells (Th1 cells)/Th2 cells at 8 weeks of intervention compared with baseline. It 
      is suggested that daily intake of fermented citrus juice containing heat-killed 
      LP0132 has beneficial effects on symptoms of perennial allergic rhinitis, and 
      these benefits may be associated with the attenuation of Th2 cells, total IgE, 
      and ECP via the immunomodulating activities of LP0132.
FAU - Harima-Mizusawa, N
AU  - Harima-Mizusawa N
AD  - 1 Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
FAU - Kano, M
AU  - Kano M
AD  - 1 Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
FAU - Nozaki, D
AU  - Nozaki D
AD  - 2 Yakult Honsha Co. Ltd, 1-19 Higashi Shimbashi 1-chome, Minato-ku, Tokyo 
      105-8660, Japan.
FAU - Nonaka, C
AU  - Nonaka C
AD  - 2 Yakult Honsha Co. Ltd, 1-19 Higashi Shimbashi 1-chome, Minato-ku, Tokyo 
      105-8660, Japan.
FAU - Miyazaki, K
AU  - Miyazaki K
AD  - 1 Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
FAU - Enomoto, T
AU  - Enomoto T
AD  - 3 NPO Japan Health Promotion Supporting Network, 3-68 Komatsubaradori, Wakayama 
      640-8269, Japan.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20160916
PL  - Netherlands
TA  - Benef Microbes
JT  - Beneficial microbes
JID - 101507616
RN  - 0 (Anti-Allergic Agents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
RN  - EC 3.1.27.- (RNASE3 protein, human)
SB  - IM
MH  - Adult
MH  - Anti-Allergic Agents/*administration & dosage
MH  - Citrus/*metabolism
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Eosinophil Cationic Protein/blood
MH  - Female
MH  - Fermentation
MH  - Fruit and Vegetable Juices/*microbiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Immunomodulation
MH  - Japan
MH  - *Lactobacillus plantarum
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic, Perennial/immunology/*prevention & control
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Type 2 helper T cells
OT  - eosinophil cationic protein
OT  - immunoglobulin E
OT  - immunomodulation
OT  - stuffy nose
EDAT- 2016/09/17 06:00
MHDA- 2017/04/07 06:00
CRDT- 2016/09/17 06:00
PHST- 2016/09/17 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
PHST- 2016/09/17 06:00 [entrez]
AID - 10.3920/BM2016.0003 [doi]
PST - ppublish
SO  - Benef Microbes. 2016 Nov 30;7(5):649-658. doi: 10.3920/BM2016.0003. Epub 2016 Sep 
      16.