PMID- 27633185
OWN - NLM
STAT- MEDLINE
DCOM- 20180103
LR  - 20220418
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 24
IP  - 1
DP  - 2017 Jan
TI  - Default mode network changes in multiple sclerosis: a link between depression and 
      cognitive impairment?
PG  - 27-36
LID - 10.1111/ene.13112 [doi]
AB  - BACKGROUND AND PURPOSE: In multiple sclerosis (MS), depression is a common 
      disorder whose pathophysiology is still debated. To gain insights into the 
      pathophysiology of depression in MS, resting-state (RS) functional connectivity 
      (FC) changes of the default mode network (DMN), salience network (SN) and 
      executive control network (ECN) were assessed in a group of depressed MS (D-MS) 
      patients and in appropriately matched control groups. METHODS: Sixteen D-MS 
      patients, 17 non-depressed MS (ND-MS) patients, 17 non-depressed healthy controls 
      and 15 depressed subjects (D-S), age, sex and education matched, cognitively 
      preserved and non-fatigued, were enrolled. All participants underwent a 
      neuropsychological evaluation and RS functional magnetic resonance imaging study. 
      RESULTS: Comparing D-MS patients with D-S, within the DMN, a significant RS-FC 
      suppression was found in the posterior cingulate cortex (PCC); comparing D-MS 
      with ND-MS, FC was significantly increased in the anterior cingulate cortex and 
      significantly reduced in the PCC. Within the SN increased FC in the right 
      supramarginal gyrus and right middle frontal gyrus was found in D-MS patients 
      compared to D-S and to ND-MS; within the ECN increased FC in the right inferior 
      parietal cortex was found in D-MS patients compared to ND-MS patients. 
      CONCLUSIONS: In cognitively preserved D-MS patients, FC derangement occurs in the 
      SN, ECN and DMN. In the latter, changes occurring both in the anterior cingulate 
      cortex and PCC suggest that depression in MS may be linked to MS itself and, in 
      particular, to a peculiar pattern of network abnormalities favored by MS 
      pathology through disconnection mechanisms. Reduced FC in the PCC, similar to MS 
      patients with cognitive impairment, suggests a functional link between depression 
      and cognitive impairment in MS.
CI  - (c) 2016 EAN.
FAU - Bonavita, S
AU  - Bonavita S
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
AD  - MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage 
      Capodimonte', Naples, Italy.
FAU - Sacco, R
AU  - Sacco R
AUID- ORCID: 0000-0002-6623-4649
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Esposito, S
AU  - Esposito S
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - d'Ambrosio, A
AU  - d'Ambrosio A
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Della Corte, M
AU  - Della Corte M
AD  - MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage 
      Capodimonte', Naples, Italy.
FAU - Corbo, D
AU  - Corbo D
AD  - MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage 
      Capodimonte', Naples, Italy.
FAU - Docimo, R
AU  - Docimo R
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Gallo, A
AU  - Gallo A
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Lavorgna, L
AU  - Lavorgna L
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Cirillo, M
AU  - Cirillo M
AD  - Neuroradiology Service, Department of Radiology, Second University of Naples, 
      Naples, Italy.
FAU - Bisecco, A
AU  - Bisecco A
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Esposito, F
AU  - Esposito F
AD  - Department of Medicine Surgery and Dentistry, University of Salerno, Salerno, 
      Italy.
FAU - Tedeschi, G
AU  - Tedeschi G
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
AD  - MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage 
      Capodimonte', Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160916
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Adult
MH  - Atrophy
MH  - Brain Mapping
MH  - Cognitive Dysfunction/etiology/*physiopathology/*psychology
MH  - Depressive Disorder/etiology/*physiopathology/*psychology
MH  - Executive Function
MH  - Female
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/complications/*physiopathology/*psychology
MH  - Nerve Net/diagnostic imaging/*physiopathology
MH  - Neuropsychological Tests
OTO - NOTNLM
OT  - cognitive impairment
OT  - default mode network
OT  - depression
OT  - multiple sclerosis
OT  - resting state f-MRI
EDAT- 2016/09/17 06:00
MHDA- 2018/01/04 06:00
CRDT- 2016/09/17 06:00
PHST- 2016/01/25 00:00 [received]
PHST- 2016/06/27 00:00 [accepted]
PHST- 2016/09/17 06:00 [pubmed]
PHST- 2018/01/04 06:00 [medline]
PHST- 2016/09/17 06:00 [entrez]
AID - 10.1111/ene.13112 [doi]
PST - ppublish
SO  - Eur J Neurol. 2017 Jan;24(1):27-36. doi: 10.1111/ene.13112. Epub 2016 Sep 16.