PMID- 27633510
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20181113
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 15
IP  - 1
DP  - 2016 Sep 15
TI  - Effects of hyperlipidaemia on plasma apolipoprotein M levels in patients with 
      type 2 diabetes mellitus: an independent case-control study.
PG  - 158
LID - 10.1186/s12944-016-0325-1 [doi]
LID - 158
AB  - BACKGROUND: Apolipoprotein M (apoM) is mainly enriched in high-density 
      lipoprotein (HDL) cholesterol and is slightly present in low-density lipoprotein 
      (LDL) cholesterol and very low-density lipoprotein cholesterol. apoM is involved 
      in HDL formation and HDL-mediated reverse cholesterol transport. apoM is also 
      associated with hyperlipidaemia and type 2 diabetes mellitus (T2DM). 
      Significantly high plasma apoM levels are detected in hyperlipidaemia mice with a 
      defective LDL receptor. By contrast, low plasma apoM levels are observed in 
      patients with T2DM, which is often accompanied with hyperlipidaemia. However, the 
      underlying mechanism of this condition is poorly understood. This research aims 
      to examine the changes in apoM levels in patients with hyperlipidaemia and to 
      determine the effects of hyperlipidaemia on plasma apoM levels in patients with 
      T2DM. METHODS: This study included patients with hyperlipidaemia (n = 79), 
      patients with T2DM but without hyperlipidaemia (n = 125), patients with T2DM and 
      hyperlipidaemia (n = 98), and healthy controls (n = 105). Their plasma apoM 
      concentrations were measured with enzyme-linked immunosorbent assay. RESULTS: The 
      average plasma apoM concentrations were 18 % higher in the hyperlipidaemia group 
      (26.63 +/- 10.35 ng/muL) than in the healthy controls (22.61 +/- 10.81 ng/muL, P 
      <0.01). The plasma apoM concentrations were lower in the T2DM without 
      hyperlipidaemia group (18.54 +/- 10.33 ng/muL, P <0.01) and the T2DM with 
      hyperlipidaemia group (19.83 +/- 7.41 ng/muL, P <0.05) than in the healthy controls. 
      Similar to apoA-I (1.29 +/- 0.33 g/L vs. 1.28 +/- 0.31 g/L, P >0.05), the plasma apoM 
      concentrations in the T2DM with hyperlipidaemia group did not significantly 
      differ from those in the T2DM without hyperlipidaemia group (P >0.05). 
      Multivariate linear regression analysis showed that hyperlipidaemia (beta = 5.18, 
      P = 0.007) is an independent promoting factor of plasma apoM levels and diabetes 
      (beta = -3.09, P = 0.005) is an inhibiting factor of plasma apoM levels. CONCLUSION: 
      Plasma apoM concentrations are higher in patients with hyperlipidaemia than in 
      healthy controls. Low plasma apoM levels in patients with T2DM are likely caused 
      by diabetes but are not induced by hyperlipidaemia.
FAU - Zhang, Puhong
AU  - Zhang P
AD  - Anhui Province Key Laboratory of Biological Macro-molecules Research (Wannan 
      Medical College), Wuhu, China.
FAU - Gao, Jialin
AU  - Gao J
AD  - Anhui Province Key Laboratory of Biological Macro-molecules Research (Wannan 
      Medical College), Wuhu, China.
AD  - Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan 
      Medical College, Wuhu, China.
FAU - Pu, Chun
AU  - Pu C
AD  - Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College, 
      Wuhu, China.
FAU - Feng, Gang
AU  - Feng G
AD  - Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College, 
      Wuhu, China.
FAU - Wang, Lizhuo
AU  - Wang L
AD  - Department of Biochemistry and Molecular Biology, Wannan Medical College, 22 West 
      Wenchang Road, Wuhu, 241002, People's Republic of China.
AD  - Anhui Province Key Laboratory of Biological Macro-molecules Research (Wannan 
      Medical College), Wuhu, China.
FAU - Huang, Lizhu
AU  - Huang L
AD  - Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College, 
      Wuhu, China.
FAU - Tao, Qingsong
AU  - Tao Q
AD  - Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College, 
      Wuhu, China.
FAU - Zhang, Yao
AU  - Zhang Y
AD  - Department of Biochemistry and Molecular Biology, Wannan Medical College, 22 West 
      Wenchang Road, Wuhu, 241002, People's Republic of China. yaozhang_wnmc@yahoo.com.
AD  - Anhui Province Key Laboratory of Biological Macro-molecules Research (Wannan 
      Medical College), Wuhu, China. yaozhang_wnmc@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20160915
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (APOM protein, human)
RN  - 0 (Apolipoproteins)
RN  - 0 (Apolipoproteins M)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipocalins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Apolipoproteins/*blood
MH  - Apolipoproteins M
MH  - Cholesterol, LDL/*blood
MH  - Diabetes Mellitus, Type 2/*blood/pathology
MH  - Female
MH  - Humans
MH  - Hyperlipidemias/*blood/pathology
MH  - Linear Models
MH  - Lipocalins/*blood
MH  - Male
MH  - Mice
MH  - Middle Aged
PMC - PMC5025546
OTO - NOTNLM
OT  - Apolipoproteins
OT  - Diabetes
OT  - Dyslipidaemia
OT  - HDL
OT  - Lipids
EDAT- 2016/09/17 06:00
MHDA- 2017/04/07 06:00
PMCR- 2016/09/15
CRDT- 2016/09/17 06:00
PHST- 2016/02/26 00:00 [received]
PHST- 2016/09/03 00:00 [accepted]
PHST- 2016/09/17 06:00 [entrez]
PHST- 2016/09/17 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
PHST- 2016/09/15 00:00 [pmc-release]
AID - 10.1186/s12944-016-0325-1 [pii]
AID - 325 [pii]
AID - 10.1186/s12944-016-0325-1 [doi]
PST - epublish
SO  - Lipids Health Dis. 2016 Sep 15;15(1):158. doi: 10.1186/s12944-016-0325-1.