PMID- 27635130
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160916
LR  - 20201001
IS  - 1687-6121 (Print)
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Linking)
VI  - 2016
DP  - 2016
TI  - Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 
      Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome.
PG  - 9256209
LID - 10.1155/2016/9256209 [doi]
LID - 9256209
AB  - Background and Aims. Although the differential expression of microRNA (miRNA) 
      genes has been identified in many diseases, little information exists concerning 
      the miRNA expression profile in type 2 diabetes mellitus (T2DM) with 
      diarrhea-predominant irritable bowel syndrome (D-IBS). Therefore, the specific 
      expression of miRNAs in diabetes with D-IBS is identified in the study. Materials 
      and Methods. 201 patients with IBS and 220 matched healthy controls were included 
      in the study. Microarray technology and real-time reverse 
      transcriptase-polymerase chain reaction analysis (RT-PCR) were taken to examine 
      the miRNA expression profiles of T2DM patients with diarrhea-predominant 
      irritable bowel syndrome (D-IBS) compared with patients with T2DM, patients with 
      D-IBS, and control subjects. Results. We have found that 35 miRNAs were 
      differentially expressed in T2DM with D-IBS, in which three representative 
      miRNAs, hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b, were found to be 
      significantly elevated in T2DM with D-IBS by RT-PCR. Conclusions. Our study has 
      indicated that hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b were elevated in T2DM 
      with D-IBS, which may be the potential biomarkers of T2DM with D-IBS. To obtain a 
      better understanding of the biological functions of these miRNAs in T2DM with 
      D-IBS, functional annotation analysis suggested that the MAPK pathway may be 
      responsible for T2DM with D-IBS.
FAU - Tao, Wenhua
AU  - Tao W
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Medical School of Yangzhou 
      University, No. 11 Huaihai Road, Yangzhou, Jiangsu 225001, China.
FAU - Dong, Xiaoyun
AU  - Dong X
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Medical School of Yangzhou 
      University, No. 11 Huaihai Road, Yangzhou, Jiangsu 225001, China.
FAU - Kong, Guimei
AU  - Kong G
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Medical School of Yangzhou 
      University, No. 11 Huaihai Road, Yangzhou, Jiangsu 225001, China.
FAU - Fang, Penghua
AU  - Fang P
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Medical School of Yangzhou 
      University, No. 11 Huaihai Road, Yangzhou, Jiangsu 225001, China.
FAU - Huang, Xiaoli
AU  - Huang X
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Medical School of Yangzhou 
      University, No. 11 Huaihai Road, Yangzhou, Jiangsu 225001, China.
FAU - Bo, Ping
AU  - Bo P
AUID- ORCID: 0000-0002-2184-7142
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Medical School of Yangzhou 
      University, No. 11 Huaihai Road, Yangzhou, Jiangsu 225001, China.
LA  - eng
PT  - Journal Article
DEP - 20160822
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC5011218
EDAT- 2016/09/17 06:00
MHDA- 2016/09/17 06:01
PMCR- 2016/08/22
CRDT- 2016/09/17 06:00
PHST- 2016/02/03 00:00 [received]
PHST- 2016/04/26 00:00 [accepted]
PHST- 2016/09/17 06:00 [entrez]
PHST- 2016/09/17 06:00 [pubmed]
PHST- 2016/09/17 06:01 [medline]
PHST- 2016/08/22 00:00 [pmc-release]
AID - 10.1155/2016/9256209 [doi]
PST - ppublish
SO  - Gastroenterol Res Pract. 2016;2016:9256209. doi: 10.1155/2016/9256209. Epub 2016 
      Aug 22.