PMID- 27635238 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160916 LR - 20201215 IS - 2046-1402 (Print) IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 5 DP - 2016 TI - EGF receptor ligands: recent advances. LID - F1000 Faculty Rev-2270 [pii] LID - 10.12688/f1000research.9025.1 [doi] AB - Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor (EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN). Of these, EGF, TGFA, HBEGF, and BTC are thought to be high-affinity ligands, whereas AREG, EREG, and EPGN constitute low-affinity ligands. This focused review is meant to highlight recent studies related to actions of the individual EGFR ligands, the interesting biology that has been uncovered, and relevant advances related to ligand interactions with the EGFR. FAU - Singh, Bhuminder AU - Singh B AD - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. FAU - Carpenter, Graham AU - Carpenter G AD - Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. FAU - Coffey, Robert J AU - Coffey RJ AD - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Veterans Health Administration, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA. LA - eng GR - P50 CA095103/CA/NCI NIH HHS/United States GR - R01 CA046413/CA/NCI NIH HHS/United States GR - R01 CA151566/CA/NCI NIH HHS/United States GR - R01 CA163563/CA/NCI NIH HHS/United States PT - Journal Article PT - Review DEP - 20160908 PL - England TA - F1000Res JT - F1000Research JID - 101594320 PMC - PMC5017282 OTO - NOTNLM OT - Amphireguin OT - Betacellulin OT - EGFR OT - Epiregulin OT - HBEGF OT - Transforming growth factor-alpha OT - epidermal growth factor OT - epigen COIS- The authors declare that they have no competing interests. No competing interests were disclosed. No competing interests were disclosed. No competing interests were disclosed. EDAT- 2016/09/17 06:00 MHDA- 2016/09/17 06:01 PMCR- 2016/09/08 CRDT- 2016/09/17 06:00 PHST- 2016/09/05 00:00 [accepted] PHST- 2016/09/17 06:00 [entrez] PHST- 2016/09/17 06:00 [pubmed] PHST- 2016/09/17 06:01 [medline] PHST- 2016/09/08 00:00 [pmc-release] AID - F1000 Faculty Rev-2270 [pii] AID - 10.12688/f1000research.9025.1 [doi] PST - epublish SO - F1000Res. 2016 Sep 8;5:F1000 Faculty Rev-2270. doi: 10.12688/f1000research.9025.1. eCollection 2016.