PMID- 27638105
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20170817
IS  - 1878-0938 (Electronic)
IS  - 1878-0938 (Linking)
VI  - 17
IP  - 8
DP  - 2016 Dec
TI  - Association of endothelial dysfunction and no-reflow during primary percutaneous 
      coronary intervention for ST-elevation myocardial infarction.
PG  - 552-555
LID - S1553-8389(16)30235-4 [pii]
LID - 10.1016/j.carrev.2016.08.013 [doi]
AB  - BACKGROUND: Coronary no-reflow during primary percutaneous coronary intervention 
      (PPCI) is a predictor of poorer cardiovascular outcome. Both endothelial 
      dysfunction and no-reflow involves abnormal vascular function and hemostasis. Our 
      aim was to assess the association between endothelial dysfunction and no reflow 
      during primary PCI. METHODS: Thirty consecutive patients with ST elevation 
      myocardial infarction (STEMI) and normal flow during primary PCI were compared to 
      19 consecutive patients who had no reflow. All subjects underwent assessment of 
      peripheral endothelial function by reactive hyperemia index (RHI) 48-72h post PCI 
      using the EndoPAT device. RESULTS: Age, sex and hypertension were similar in both 
      groups. Smokers were less likely to have no-reflow. Post PPCI there was less ST 
      segment resolution in the no-reflow group (48%+/-7 vs. 81%+/-6; p=0.001). Patients 
      who had no reflow had subsequently lower ejection fraction (39%+/-10 vs. 47%+/-10; 
      p=0.015). There was no difference in vascular function (RHI), between the 
      no-reflow and normal flow groups (1.91+/-0.3 vs. 2.09+/-0.11; p=0.24). CONCLUSIONS: 
      Systemic peripheral endothelial function does not differ between STEMI patients 
      with and without no reflow during primary PCI.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Levi, Yaniv
AU  - Levi Y
AD  - Western University, N6A 5A5 London, ON, Canada; London Health Sciences Centre, 
      N6A 5A5 London, ON, Canada.
FAU - Sultan, Ayyaz
AU  - Sultan A
AD  - Western University, N6A 5A5 London, ON, Canada; London Health Sciences Centre, 
      N6A 5A5 London, ON, Canada.
FAU - Alemayehu, Mistre
AU  - Alemayehu M
AD  - London Health Sciences Centre, N6A 5A5 London, ON, Canada.
FAU - Wall, Sabrina
AU  - Wall S
AD  - London Health Sciences Centre, N6A 5A5 London, ON, Canada.
FAU - Lavi, Shahar
AU  - Lavi S
AD  - Western University, N6A 5A5 London, ON, Canada; London Health Sciences Centre, 
      N6A 5A5 London, ON, Canada. Electronic address: Shahar.Lavi@lhsc.on.ca.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160903
PL  - United States
TA  - Cardiovasc Revasc Med
JT  - Cardiovascular revascularization medicine : including molecular interventions
JID - 101238551
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Hyperemia/physiopathology
MH  - Male
MH  - Manometry
MH  - Microcirculation
MH  - Middle Aged
MH  - No-Reflow Phenomenon/diagnosis/*etiology/physiopathology
MH  - Ontario
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Regional Blood Flow
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/diagnosis/physiopathology/*therapy
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Upper Extremity/*blood supply
OTO - NOTNLM
OT  - Acute MI
OT  - Angiography
OT  - No-reflow
EDAT- 2016/09/18 06:00
MHDA- 2017/02/28 06:00
CRDT- 2016/09/18 06:00
PHST- 2016/04/27 00:00 [received]
PHST- 2016/08/25 00:00 [revised]
PHST- 2016/08/31 00:00 [accepted]
PHST- 2016/09/18 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
PHST- 2016/09/18 06:00 [entrez]
AID - S1553-8389(16)30235-4 [pii]
AID - 10.1016/j.carrev.2016.08.013 [doi]
PST - ppublish
SO  - Cardiovasc Revasc Med. 2016 Dec;17(8):552-555. doi: 10.1016/j.carrev.2016.08.013. 
      Epub 2016 Sep 3.