PMID- 27638745 OWN - NLM STAT- MEDLINE DCOM- 20191023 LR - 20240130 IS - 1532-6551 (Electronic) IS - 1071-3581 (Linking) VI - 25 IP - 3 DP - 2018 Jun TI - Feasibility of FDG-PET in myocarditis: Comparison to CMR using integrated PET/MRI. PG - 785-794 LID - 10.1007/s12350-016-0616-y [doi] AB - OBJECTIVE: Besides cardiac sarcoidosis, FDG-PET is rarely used in the diagnosis of myocardial inflammation, while cardiac MRI (CMR) is the actual imaging reference for the workup of myocarditis. Using integrated PET/MRI in patients with suspected myocarditis, we prospectively compared FDG-PET to CMR and the feasibility of integrated FDG-PET/MRI in myocarditis. METHODS: A total of 65 consecutive patients with suspected myocarditis were prospectively assessed using integrated cardiac FDG-PET/MRI. Studies comprised T2-weighted imaging, late gadolinium enhancement (LGE), and simultaneous PET acquisition. Physiological glucose uptake in the myocardium was suppressed using dietary preparation. RESULTS: FDG-PET/MRI was successful in 55 of 65 enrolled patients: two patients were excluded due to claustrophobia and eight patients due to failed inhibition of myocardial glucose uptake. Compared with CMR (LGE and/or T2), sensitivity and specificity of PET was 74% and 97%. Overall spatial agreement between PET and CMR was kappa = 0.73. Spatial agreement between PET and T2 (kappa = 0.75) was higher than agreement between PET and LGE (kappa = 0.64) as well as between LGE and T2 (kappa = 0.56). CONCLUSION: In patients with suspected myocarditis, FDG-PET is in good agreement with CMR findings. FAU - Nensa, Felix AU - Nensa F AD - Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. felix.nensa@uk-essen.de. FAU - Kloth, Julia AU - Kloth J AD - Clinic for Cardiology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany. FAU - Tezgah, Ercan AU - Tezgah E AD - Clinic for Cardiology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany. FAU - Poeppel, Thorsten D AU - Poeppel TD AD - Clinic for Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany. FAU - Heusch, Philipp AU - Heusch P AD - Department of Diagnostic and Interventional Radiology, University Hospital Dusseldorf, University of Dusseldorf, 45147, Dusseldorf, Germany. FAU - Goebel, Juliane AU - Goebel J AD - Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. FAU - Nassenstein, Kai AU - Nassenstein K AD - Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. FAU - Schlosser, Thomas AU - Schlosser T AD - Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. LA - eng PT - Journal Article DEP - 20160908 PL - United States TA - J Nucl Cardiol JT - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology JID - 9423534 RN - 0 (Contrast Media) RN - 0 (Radiopharmaceuticals) RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) RN - AU0V1LM3JT (Gadolinium) SB - IM CIN - J Nucl Cardiol. 2018 Jun;25(3):795-796. PMID: 27663252 MH - Adult MH - Contrast Media MH - Feasibility Studies MH - Female MH - *Fluorodeoxyglucose F18 MH - Gadolinium MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Multimodal Imaging MH - Myocarditis/*diagnostic imaging MH - *Positron-Emission Tomography MH - Prospective Studies MH - *Radiopharmaceuticals OTO - NOTNLM OT - Fluorodeoxyglucose (FDG) OT - PET imaging OT - PET/MR imaging OT - cardiovascular magnetic OT - myocarditis OT - resonance imaging EDAT- 2016/09/18 06:00 MHDA- 2019/10/24 06:00 CRDT- 2016/09/18 06:00 PHST- 2016/06/18 00:00 [received] PHST- 2016/07/14 00:00 [revised] PHST- 2016/09/18 06:00 [pubmed] PHST- 2019/10/24 06:00 [medline] PHST- 2016/09/18 06:00 [entrez] AID - S1071-3581(23)02253-5 [pii] AID - 10.1007/s12350-016-0616-y [doi] PST - ppublish SO - J Nucl Cardiol. 2018 Jun;25(3):785-794. doi: 10.1007/s12350-016-0616-y. Epub 2016 Sep 8.