PMID- 27638968
OWN - NLM
STAT- MEDLINE
DCOM- 20171208
LR  - 20220316
IS  - 1873-7714 (Electronic)
IS  - 0163-8343 (Linking)
VI  - 42
DP  - 2016 Sep-Oct
TI  - Associations between immune activation and the current severity of the "with 
      anxious distress" specifier in patients with depressive disorders.
PG  - 27-31
LID - S0163-8343(16)30107-4 [pii]
LID - 10.1016/j.genhosppsych.2016.07.003 [doi]
AB  - OBJECTIVE: Immune dysregulation may be linked with depressive disorders and in 
      particular anxiety symptoms. This study compared the levels of immune factors, 
      demographic and clinical characteristics of patients with depressive disorders 
      between mild to moderate and moderate-severe to severe anxious distress groups. 
      METHODS: This study included 177 patients diagnosed with a depressive disorder 
      who were hospitalized between March 2012 and April 2015. The patients were 
      categorized into mild to moderate and moderate-severe to severe anxious distress 
      groups, based on the Hamilton Depression Rating Scale (HAM-D) scores on the 
      Agitation and Anxiety-Psychic subscales. The charts of the patients were reviewed 
      to evaluate immune factors, including C-reactive protein (CRP) and white blood 
      cell levels, confounding factors, such as smoking, other general medical 
      disorders and body mass index, and demographic and clinical characteristics, such 
      as age, sex, total HAM-D scores, comorbidities, family history of mood disorders, 
      suicidality, psychotic features and prescription patterns. RESULTS: The 
      moderate-severe to severe group tended to have higher CRP and monocyte levels 
      compared with the mild to moderate group. After adjusting for the HAM-D scores, 
      patients with moderate-severe to severe anxious distress had a significantly 
      greater trend toward significance for suicidality and a higher rate of 
      antipsychotic use. CONCLUSION: High levels of anxiety symptoms may modulate the 
      inflammatory response and course of illness, affecting treatment planning.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Shim, In Hee
AU  - Shim IH
AD  - Department of Psychiatry, Cancer center, Dongnam Institute of Radiological & 
      Medical Sciences, Busan, Republic of Korea. Electronic address: 
      ihshim1224@gmail.com.
FAU - Woo, Young Sup
AU  - Woo YS
AD  - Department of Psychiatry, College of Medicine, The Catholic University of Korea, 
      Seoul, Republic of Korea.
FAU - Bahk, Won-Myong
AU  - Bahk WM
AD  - Department of Psychiatry, College of Medicine, The Catholic University of Korea, 
      Seoul, Republic of Korea. Electronic address: wmbahk@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20160712
PL  - United States
TA  - Gen Hosp Psychiatry
JT  - General hospital psychiatry
JID - 7905527
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anxiety Disorders/blood/epidemiology/*immunology
MH  - *C-Reactive Protein
MH  - Comorbidity
MH  - Depressive Disorder/blood/epidemiology/*immunology
MH  - Female
MH  - Humans
MH  - Inflammation/blood/epidemiology/*immunology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Anxiety
OT  - C-reactive protein
OT  - Depression
OT  - Immune
OT  - Monocyte
EDAT- 2016/09/18 06:00
MHDA- 2017/12/09 06:00
CRDT- 2016/09/18 06:00
PHST- 2016/05/27 00:00 [received]
PHST- 2016/07/05 00:00 [revised]
PHST- 2016/07/08 00:00 [accepted]
PHST- 2016/09/18 06:00 [entrez]
PHST- 2016/09/18 06:00 [pubmed]
PHST- 2017/12/09 06:00 [medline]
AID - S0163-8343(16)30107-4 [pii]
AID - 10.1016/j.genhosppsych.2016.07.003 [doi]
PST - ppublish
SO  - Gen Hosp Psychiatry. 2016 Sep-Oct;42:27-31. doi: 
      10.1016/j.genhosppsych.2016.07.003. Epub 2016 Jul 12.