PMID- 27640070
OWN - NLM
STAT- MEDLINE
DCOM- 20170529
LR  - 20180415
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 151
DP  - 2016 Nov
TI  - Association between serum concentrations of persistent organic pollutants and 
      gestational diabetes mellitus in primiparous women.
PG  - 706-712
LID - S0013-9351(16)30540-0 [pii]
LID - 10.1016/j.envres.2016.09.002 [doi]
AB  - BACKGROUND: There is growing evidence that persistent organic pollutants (POPs) 
      may play an important role in increasing the risk of gestational diabetes 
      mellitus (GDM). OBJECTIVES: The aim of this study was to examine the association 
      between polychlorinated biphenyls (PCBs, 10 congeners) and polybrominated 
      diphenyl ethers (PBDEs, 8 congeners) and GDM in primiparous women with no family 
      history of diabetes in first-degree relatives during the third trimester of 
      pregnancy. METHODS: This case-control study was performed among the three 
      university hospitals of Tehran University of Medical Sciences. Serum samples were 
      collected from cases (n=70) that were diagnosed with GDM and from controls (n=70) 
      with a normal pregnancy that attended the same hospital for a routine prenatal 
      visit. Pollutant levels were analyzed by Gas Chromatography Mass Spectrometry 
      (GC/MS). RESULTS: Logistic regression analyses manifested the positive 
      association between total POPs (sum of total PCBs and PBDEs) (Odds ratio 
      (OR)=1.61, 95% CI: 1.31-1.97, p-value <0.0001) and total PCBs (OR=1.75, 95% CI: 
      1.35-2.27, p-value<0.0001) and GDM considering confounding variables (age, 
      gestational age, pre-pregnancy body mass index (BMI), and total maternal serum 
      lipid). In addition, we found a positive association between total PBDEs and GDM 
      (OR =2.21; 95% CI: 1.48-3.30, p-value <0.0001). Finally, we found a positive 
      association between Ln PCB 187, 118 and Ln PBDE 99, 28 with GDM. Meanwhile a 
      negative association between Ln PCB 28 and GDM was established. CONCLUSION: Our 
      data suggest that exposure to certain POPs (PCBs and PBDEs) could be a potential 
      modifying risk factor for GDM.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Eslami, Bita
AU  - Eslami B
AD  - Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Naddafi, Kazem
AU  - Naddafi K
AD  - Center for Air Pollution Research (CAPR), Institute for Environmental Research 
      (IER), Tehran University of Medical Sciences, Tehran, Iran.
FAU - Rastkari, Noushin
AU  - Rastkari N
AD  - Center for Air Pollution Research (CAPR), Institute for Environmental Research 
      (IER), Tehran University of Medical Sciences, Tehran, Iran.
FAU - Rashidi, Batool Hossein
AU  - Rashidi BH
AD  - Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Djazayeri, Abolghasem
AU  - Djazayeri A
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Malekafzali, Hossein
AU  - Malekafzali H
AD  - Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran. Electronic address: malek179@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160916
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 7REL09ZX35 (pentabromodiphenyl ether)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes, Gestational/*blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Gestational Age
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Iran
MH  - Logistic Models
MH  - Maternal Exposure/*adverse effects
MH  - Parity
MH  - Polychlorinated Biphenyls/*blood
MH  - Pregnancy
OTO - NOTNLM
OT  - Case-control study
OT  - Gestational Diabetes Mellitus
OT  - Persistent Organic Pollutants (POPs)
OT  - Polybrominated Diphenyl Ethers (PBDEs)
OT  - Polychlorinated Biphenyls (PCBs)
EDAT- 2016/10/21 06:00
MHDA- 2017/05/30 06:00
CRDT- 2016/09/19 06:00
PHST- 2016/04/10 00:00 [received]
PHST- 2016/08/28 00:00 [revised]
PHST- 2016/09/05 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/05/30 06:00 [medline]
PHST- 2016/09/19 06:00 [entrez]
AID - S0013-9351(16)30540-0 [pii]
AID - 10.1016/j.envres.2016.09.002 [doi]
PST - ppublish
SO  - Environ Res. 2016 Nov;151:706-712. doi: 10.1016/j.envres.2016.09.002. Epub 2016 
      Sep 16.