PMID- 27641082
OWN - NLM
STAT- MEDLINE
DCOM- 20170130
LR  - 20170130
IS  - 2213-3941 (Electronic)
IS  - 0003-4266 (Linking)
VI  - 77
IP  - 6
DP  - 2016 Dec
TI  - Association between DNA methylation of SORL1 5'-flanking region and mild 
      cognitive impairment in type 2 diabetes mellitus.
PG  - 625-632
LID - S0003-4266(16)30098-1 [pii]
LID - 10.1016/j.ando.2016.02.008 [doi]
AB  - OBJECTIVES: In the present study, we examined whether DNA methylation of the 
      sortilin-related receptor 1 (SORL1) 5'-flanking region is associated with the 
      manifestation and clinical presentation of mild cognitive impairment in type 2 
      diabetes mellitus (T2DM). METHODS: Of 84 diabetic patients with mild cognitive 
      impairment (MCI group), 78 diabetic patients without mild cognitive impairment 
      (NMCI group) and 80 age-matched normal controls (NC group), the DNA methylation 
      of the SORL1 5'-flanking region was completely analyzed. The SORL1 methylation 
      ratios of the above three groups were compared statistically. Next, we 
      investigated the correlation between the DNA methylation status and the clinical 
      presentation of diabetes with or without cognitive impairment (MCI and NMCI 
      groups). RESULTS: The methylation ratio (86.9%) of MCI patients was significantly 
      higher than that in the NMCI patients (35.9%, P<0.05) and in the NC group (11.3%, 
      P<0.05). Moreover, the diabetic patients with methylation alleles had greater 
      ages, longer diabetes duration, lower MOCA scores and higher plasma amyloid Abeta 
      1-42 levels than those with unmethylation alleles (P<0.05). CONCLUSION: These 
      results suggested that the DNA methylation of the SORL1 5'-flanking region may 
      significantly influence the manifestation of mild cognitive impairment in T2DM, 
      and might be associated with its neurocognitive presentation.
CI  - Copyright A(c) 2016 Elsevier Masson SAS. All rights reserved.
FAU - Yu, Yang
AU  - Yu Y
AD  - Endocrinology department of Affiliated Zhongshan Hospital of Dalian University, 6 
      JieFang Street, Zhongshan District, DaLian, 116001 Liaoning, PR China. Electronic 
      address: someso@sina.com.
FAU - Mingjiao, Wang
AU  - Mingjiao W
AD  - Endocrinology department of Affiliated Zhongshan Hospital of Dalian University, 6 
      JieFang Street, Zhongshan District, DaLian, 116001 Liaoning, PR China.
FAU - Yang, Xiaohui
AU  - Yang X
AD  - Endocrinology department of Affiliated Zhongshan Hospital of Dalian University, 6 
      JieFang Street, Zhongshan District, DaLian, 116001 Liaoning, PR China.
FAU - Sui, Miao
AU  - Sui M
AD  - Endocrinology department of Affiliated Zhongshan Hospital of Dalian University, 6 
      JieFang Street, Zhongshan District, DaLian, 116001 Liaoning, PR China.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Endocrinology department of Affiliated Zhongshan Hospital of Dalian University, 6 
      JieFang Street, Zhongshan District, DaLian, 116001 Liaoning, PR China.
FAU - Liang, Jin
AU  - Liang J
AD  - Neurology department of Affiliated Zhongshan Hospital of Dalian University, 
      DaLian, 116001 Liaoning, PR China.
FAU - Gu, Xinyi
AU  - Gu X
AD  - Neurology department of Affiliated Zhongshan Hospital of Dalian University, 
      DaLian, 116001 Liaoning, PR China.
FAU - Wang, Xiaomei
AU  - Wang X
AD  - Endocrinology department of Affiliated Zhongshan Hospital of Dalian University, 6 
      JieFang Street, Zhongshan District, DaLian, 116001 Liaoning, PR China.
LA  - eng
PT  - Journal Article
DEP - 20160915
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
RN  - 0 (LDL-Receptor Related Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (SORL1 protein, human)
SB  - IM
MH  - 5' Flanking Region/*genetics
MH  - Aged
MH  - Case-Control Studies
MH  - Cognition Disorders/genetics
MH  - Cognitive Dysfunction/complications/*genetics
MH  - *DNA Methylation
MH  - Diabetes Complications/genetics
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - LDL-Receptor Related Proteins/*genetics
MH  - Male
MH  - Membrane Transport Proteins/*genetics
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Deficience cognitive legere
OT  - Methylation
OT  - Methylation-specific PCR
OT  - Mild cognitive impairment
OT  - Methylation
OT  - Methylation par PCR
OT  - SORL1
EDAT- 2016/09/20 06:00
MHDA- 2017/01/31 06:00
CRDT- 2016/09/20 06:00
PHST- 2016/01/19 00:00 [received]
PHST- 2016/02/17 00:00 [revised]
PHST- 2016/02/29 00:00 [accepted]
PHST- 2016/09/20 06:00 [pubmed]
PHST- 2017/01/31 06:00 [medline]
PHST- 2016/09/20 06:00 [entrez]
AID - S0003-4266(16)30098-1 [pii]
AID - 10.1016/j.ando.2016.02.008 [doi]
PST - ppublish
SO  - Ann Endocrinol (Paris). 2016 Dec;77(6):625-632. doi: 10.1016/j.ando.2016.02.008. 
      Epub 2016 Sep 15.