PMID- 27642354
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160919
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2016
DP  - 2016
TI  - The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable 
      Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF 
      Signaling Pathway in Rats.
PG  - 7434692
LID - 10.1155/2016/7434692 [doi]
LID - 7434692
AB  - Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical 
      effects on menstrual illness, cerebrovascular diseases, cardiovascular diseases, 
      and cognitive impairments. However, until recently, few studies had explored its 
      antidepressant effect. The current study attempts to investigate the effect of AS 
      extracts on chronic unpredictable mild stress- (CUMS-) induced depression in 
      rats. Male SD rats were exposed to a CUMS-inducing procedure for 5 weeks, 
      resulting in rodent depressive behaviors that included reduced sucrose 
      consumption and lessened sucrose preference ratios in sucrose preference test, 
      prolonged immobility times and decreased struggling time in force swim test, and 
      decreased locomotor activity in open field test. Moreover, the expression of 
      brain derived neurotrophic factor (BDNF) and the phosphorylation of cAMP-response 
      element binding protein (CREB) and extracellular signal-regulated protein kinase 
      (ERK 1/2) were markedly decreased in the hippocampus in depressed rats. However, 
      chronically treating the depressed rats with AS (1 g/kg) normalized their 
      depression-related behaviors and molecular profiles. In conclusion, in the 
      present study, we show that AS extracts exerted antidepressant effects that were 
      mediated by the BDNF signaling pathway: in AS-treated depressed rats, the 
      expression of the BDNF protein and the phosphorylation of its downstream targets 
      (ERK 1/2, CREB) were upregulated in the hippocampus.
FAU - Shen, Jun
AU  - Shen J
AUID- ORCID: 0000-0001-5992-4564
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No. 169, Donghu 
      Road, Wuhan, Hubei 430071, China.
FAU - Zhang, Junjian
AU  - Zhang J
AUID- ORCID: 0000-0002-4557-5137
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No. 169, Donghu 
      Road, Wuhan, Hubei 430071, China.
FAU - Deng, Min
AU  - Deng M
AUID- ORCID: 0000-0002-1497-9964
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No. 169, Donghu 
      Road, Wuhan, Hubei 430071, China.
FAU - Liu, Yue
AU  - Liu Y
AUID- ORCID: 0000-0001-7866-5887
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No. 169, Donghu 
      Road, Wuhan, Hubei 430071, China.
FAU - Hu, Yuan
AU  - Hu Y
AUID- ORCID: 0000-0001-9860-7799
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No. 169, Donghu 
      Road, Wuhan, Hubei 430071, China.
FAU - Zhang, Lei
AU  - Zhang L
AUID- ORCID: 0000-0003-3485-2298
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No. 169, Donghu 
      Road, Wuhan, Hubei 430071, China.
LA  - eng
PT  - Journal Article
DEP - 20160825
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5014956
EDAT- 2016/09/20 06:00
MHDA- 2016/09/20 06:01
PMCR- 2016/08/25
CRDT- 2016/09/20 06:00
PHST- 2016/05/24 00:00 [received]
PHST- 2016/07/06 00:00 [revised]
PHST- 2016/07/28 00:00 [accepted]
PHST- 2016/09/20 06:00 [entrez]
PHST- 2016/09/20 06:00 [pubmed]
PHST- 2016/09/20 06:01 [medline]
PHST- 2016/08/25 00:00 [pmc-release]
AID - 10.1155/2016/7434692 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2016;2016:7434692. doi: 10.1155/2016/7434692. 
      Epub 2016 Aug 25.