PMID- 27642535
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160919
LR  - 20220409
IS  - 2090-8083 (Print)
IS  - 2042-0080 (Electronic)
IS  - 2042-0080 (Linking)
VI  - 2016
DP  - 2016
TI  - The Effect of Hyperhomocysteinemia on Motor Symptoms, Cognitive Status, and 
      Vascular Risk in Patients with Parkinson's Disease.
PG  - 1589747
LID - 10.1155/2016/1589747 [doi]
LID - 1589747
AB  - Factors related with hyperhomocysteinemia (HHcy) and the impact of HHcy in 
      Parkinson's disease (PD) are not well understood. We investigated the factors 
      associated with increased levels of homocysteine (Hcy) and the relationship 
      between HHcy and motor symptoms, cognitive status, and vascular risk in patients 
      with Parkinson's disease. Among 60 patients (29 males, 48.3%) with PD, the stage 
      of the disease, the severity of clinical symptoms, and the patients' cognitive 
      status were measured using a modified Hoehn and Yahr Staging Scale (mHY), Unified 
      Parkinson's Disease Rating Scale (UPDRS) II and III, and Mini-Mental State 
      Examination (MMSE), respectively. Patients were also noted for having dyskinesia 
      and hallucinations. Serum vitamin B12, folic acid, and plasma Hcy levels were 
      measured. Furthermore, the presence of vascular risk factors was recorded. 
      Finally, we investigated carotid artery intima-media thickening and stenosis 
      using colour Doppler ultrasonography as well as the presence of ischemic lesions 
      using brain imaging techniques. Plasma Hcy levels were higher with advanced age 
      and in males. In addition, there was an inverse relationship between Hcy and 
      vitamin B12 levels. There was no correlation between HHcy and the stage of the 
      disease, severity of motor symptoms, cognitive status as assessed by the MMSE, 
      vascular risk factors, carotid artery atherosclerotic findings, and ischemic 
      brain lesions. Plasma Hcy levels may rise due to several factors in PD. However, 
      the resulting HHcy has no significant effect on the clinical picture in terms of 
      motor features, cognitive status, and vascular diseases.
FAU - Kocer, Bilge
AU  - Kocer B
AUID- ORCID: 0000-0001-5436-8618
AD  - Department of Neurology, Diskapi Yildirim Beyazit Training and Research Hospital, 
      06110 Ankara, Turkey.
FAU - Guven, Hayat
AU  - Guven H
AD  - Department of Neurology, Diskapi Yildirim Beyazit Training and Research Hospital, 
      06110 Ankara, Turkey.
FAU - Conkbayir, Isik
AU  - Conkbayir I
AD  - Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, 
      06110 Ankara, Turkey.
FAU - Comoglu, Selim Selcuk
AU  - Comoglu SS
AD  - Department of Neurology, Diskapi Yildirim Beyazit Training and Research Hospital, 
      06110 Ankara, Turkey.
FAU - Delibas, Sennur
AU  - Delibas S
AD  - Department of Neurology, Diskapi Yildirim Beyazit Training and Research Hospital, 
      06110 Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160825
PL  - United States
TA  - Parkinsons Dis
JT  - Parkinson's disease
JID - 101539877
PMC - PMC5014982
EDAT- 2016/09/20 06:00
MHDA- 2016/09/20 06:01
PMCR- 2016/08/25
CRDT- 2016/09/20 06:00
PHST- 2016/02/07 00:00 [received]
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/09/20 06:00 [entrez]
PHST- 2016/09/20 06:00 [pubmed]
PHST- 2016/09/20 06:01 [medline]
PHST- 2016/08/25 00:00 [pmc-release]
AID - 10.1155/2016/1589747 [doi]
PST - ppublish
SO  - Parkinsons Dis. 2016;2016:1589747. doi: 10.1155/2016/1589747. Epub 2016 Aug 25.