PMID- 27645337
OWN - NLM
STAT- MEDLINE
DCOM- 20170228
LR  - 20170228
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 9
DP  - 2016 Sep
TI  - How long does it take to diagnose patients with neuromyelitis optica (NMO) using 
      the 2006 diagnostic criteria?
PG  - 14-6
LID - S2211-0348(16)30090-6 [pii]
LID - 10.1016/j.msard.2016.06.006 [doi]
AB  - BACKGROUND AND PURPOSE: A few reports studied the time use to diagnose patient 
      with neuromyelitis optica (NMO). The Aim of the study is to evaluate the interval 
      from disease onset to the time when patients fulfilled the NMO diagnostic 
      criteria 2006 in Thai. METHOD: A retrospective study of the NMO patients visiting 
      the MS clinic and related disorders at Siriraj hospital was reviewed. RESULTS: 
      There were 42 definite NMO. All were female. The most common first presentations 
      were optic neuritis (ON) (45.2%), transverse myelitis (TM) (35.7%), ON and TM 
      (9.5%) and brainstem symptoms (9.5%), respectively. The mean age at onset of 
      their ON and TM attack was 33.4 and 38.4 years, respectively. Anti-AQP4 antibody 
      was presented in 82% using cell based assay. For those presented with ON, 7.1% 
      reported painful eye movements and 33.3% had bilateral involvement. Brain MRI not 
      compatible with MS was found in 94.87%. In who presented with TM, 87.8% revealed 
      long extensive transverse myelitis (LETM) in spinal MRI. The presence of 
      CSF-oligoclonal band (CSF-OCB) was found in 14.6%. Our NMO patients had the 
      average number of the attack of 1.5 times before the diagnosis could be made. 
      Nearly fifty-five percent of NMO patients fulfilled the NMO diagnostic criteria 
      2006 within 1 year after disease onset and 90.5% within 5 years CONCLUSION: About 
      half of Thai patients with definite NMO were diagnosed within 1 year and 
      approximately 90% within 5 years from their disease onset.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Tengsirikomol, Tanawat
AU  - Tengsirikomol T
AD  - Division of Neurology, Faculty of Medicine Siriraj Hospital, Mahidol University, 
      Bangkok 10700, Thailand. Electronic address: armswu@hotmail.com.
FAU - Siritho, Sasitorn
AU  - Siritho S
AD  - Division of Neurology, Faculty of Medicine Siriraj Hospital, Mahidol University, 
      Bangkok 10700, Thailand; Bumrungrad International Hospital, Bangkok 10110, 
      Thailand. Electronic address: siritho@yahoo.com.
FAU - Prayoonwiwat, Naraporn
AU  - Prayoonwiwat N
AD  - Division of Neurology, Faculty of Medicine Siriraj Hospital, Mahidol University, 
      Bangkok 10700, Thailand. Electronic address: naraporn.pra@mahidol.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20160611
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain/diagnostic imaging
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Neuromyelitis Optica/*diagnosis/diagnostic imaging/epidemiology/physiopathology
MH  - Retrospective Studies
MH  - Spinal Cord/diagnostic imaging
MH  - Thailand/epidemiology
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Definite NMO
OT  - Diagnostic criteria 2006
OT  - Thai
OT  - Time to diagnosis
EDAT- 2016/09/21 06:00
MHDA- 2017/03/01 06:00
CRDT- 2016/09/21 06:00
PHST- 2016/01/12 00:00 [received]
PHST- 2016/06/08 00:00 [revised]
PHST- 2016/06/10 00:00 [accepted]
PHST- 2016/09/21 06:00 [entrez]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/03/01 06:00 [medline]
AID - S2211-0348(16)30090-6 [pii]
AID - 10.1016/j.msard.2016.06.006 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2016 Sep;9:14-6. doi: 10.1016/j.msard.2016.06.006. Epub 
      2016 Jun 11.