PMID- 27645343
OWN - NLM
STAT- MEDLINE
DCOM- 20170228
LR  - 20170228
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 9
DP  - 2016 Sep
TI  - Interferon beta associated nephropathy in a Multiple Sclerosis patient: A case and 
      review.
PG  - 50-3
LID - S2211-0348(16)30096-7 [pii]
LID - 10.1016/j.msard.2016.06.012 [doi]
AB  - BACKGROUND: Interferon beta (IFN beta) subtypes are largely used as immunomodulatory 
      agents in Multiple Sclerosis (MS) treatment. While being generally well 
      tolerated, they can cause various side effects. Adverse effects related to kidney 
      are rarely reported. CASE REPORT: We report a 32 years old male patient who 
      developed nephrotic syndrome while receiving IFN beta for MS. Biopsy showed focal 
      segmental glomerulosclerosis. He went into remisson after cessation of drug and 
      with the aid of angiotensin II antagonists. Here, we report this case and a 
      review of similar cases reported in literature. CONCLUSIONS: Although it's a rare 
      adverse effect and tend to show good prognosis physicians should pay careful 
      attention to symptoms and findings of nephropathy during follow ups of patients 
      under treatment with these agents.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Ozturk, Musa
AU  - Ozturk M
AD  - Department of Neurology, Bakirkoy Research and Training Hospital for Psychiatry, 
      Neurology and Neurosurgery, Tevfik Saglam Cad No:25/2, 34147 Bakirkoy, Istanbul, 
      Turkey. Electronic address: musaozturk2001@yahoo.com.
FAU - Basoglu, Fulya
AU  - Basoglu F
AD  - Department of Neurology, Bakirkoy Research and Training Hospital for Psychiatry, 
      Neurology and Neurosurgery, Tevfik Saglam Cad No:25/2, 34147 Bakirkoy, Istanbul, 
      Turkey. Electronic address: fbasoglu_crh@hotmail.com.
FAU - Yilmaz, Murvet
AU  - Yilmaz M
AD  - Department of Nephrology, Bakirkoy Dr Sadi Konuk Reasaerch and Training Hospital, 
      Tevfik Saglam Street No:11, 34147 Bakirkoy, Istanbul, Turkey. Electronic address: 
      murvetyilmaz@hotmail.com.
FAU - Ozagari, Ayse Aysim
AU  - Ozagari AA
AD  - Department of Pathology, Sisli Hamidiye Etfal Research and Training Hospital, 
      Halaskargazi Boulevard, Etfal Street, 34360 Sisli, Istanbul, Turkey. Electronic 
      address: aaozagari@gmail.com.
FAU - Baybas, Sevim
AU  - Baybas S
AD  - Department of Neurology, Bakirkoy Research and Training Hospital for Psychiatry, 
      Neurology and Neurosurgery, Tevfik Saglam Cad No:25/2, 34147 Bakirkoy, Istanbul, 
      Turkey. Electronic address: baybas@gmail.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20160627
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Adjuvants, Immunologic)
RN  - XRO4566Q4R (Interferon beta-1a)
SB  - IM
MH  - Adjuvants, Immunologic/*adverse effects/therapeutic use
MH  - Adult
MH  - Humans
MH  - Interferon beta-1a/*adverse effects/therapeutic use
MH  - Kidney/drug effects/pathology
MH  - Male
MH  - Multiple Sclerosis/complications/*drug therapy/pathology
MH  - Nephrotic Syndrome/*chemically induced/complications/drug therapy/pathology
OTO - NOTNLM
OT  - Interferon beta
OT  - Multiple Sclerosis
OT  - Nephrotic syndrome
EDAT- 2016/09/21 06:00
MHDA- 2017/03/01 06:00
CRDT- 2016/09/21 06:00
PHST- 2016/01/17 00:00 [received]
PHST- 2016/04/12 00:00 [revised]
PHST- 2016/06/25 00:00 [accepted]
PHST- 2016/09/21 06:00 [entrez]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/03/01 06:00 [medline]
AID - S2211-0348(16)30096-7 [pii]
AID - 10.1016/j.msard.2016.06.012 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2016 Sep;9:50-3. doi: 10.1016/j.msard.2016.06.012. Epub 
      2016 Jun 27.