PMID- 2764637
OWN - NLM
STAT- MEDLINE
DCOM- 19890914
LR  - 20220309
IS  - 0167-4943 (Print)
IS  - 0167-4943 (Linking)
VI  - 8
IP  - 3
DP  - 1989 May
TI  - Effects of idebenone on neurological deficits, local cerebral blood flow, and 
      energy metabolism in rats with experimental cerebral ischemia.
PG  - 193-202
AB  - Improvement of energy metabolism in ischemic cerebral tissue benefits the therapy 
      of occlusive cerebrovascular disorders. In the present study, the effects of 
      6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on 
      neurological signs, such as ischemic seizures, lactate and ATP contents of the 
      cerebral cortex, and local cerebral blood flow, were assessed in stroke-prone 
      spontaneously hypertensive rats (SHRSP) with experimentally induced cerebral 
      ischemia. Experimental cerebral ischemia was caused by bilateral carotid artery 
      occlusion (BCAO) in male SHRSP (8-10 weeks old). Pretreatment with idebenone 
      (10-100 mg/kg, p.o.) for 3 or 10 days delayed the onset of ischemic seizure 
      (acute stroke) and prolonged survival time in SHRSP roughly in a dose-dependent 
      manner. When the compound (100 mg/kg, i.p.) was given once 30 min after BCAO, it 
      exerted similar ameliorating effects on the neurological deficits. When idebenone 
      (100 mg/kg for 3 days) was given orally, it did not significantly inhibit the 
      decrease in regional cerebral blood flow induced by BCAO. However, the same 
      treatment markedly inhibited increases in the lactate content and 
      lactate/pyruvate ratio and the decrease in ATP content of the cerebral cortex. 
      The compound did not affect cerebral blood flow in normal rats. These results 
      suggest that idebenone ameliorates the neurological deficits related to cerebral 
      ischemia, and that this effect is mediated by improving cerebral energy 
      metabolism.
FAU - Nagaoka, A
AU  - Nagaoka A
AD  - Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
FAU - Suno, M
AU  - Suno M
FAU - Shibota, M
AU  - Shibota M
FAU - Kakihana, M
AU  - Kakihana M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Benzoquinones)
RN  - 0 (Quinones)
RN  - 1339-63-5 (Ubiquinone)
RN  - DAA13NKG2Q (Papaverine)
RN  - HB6PN45W4J (idebenone)
SB  - IM
MH  - Animals
MH  - *Benzoquinones
MH  - Brain/*drug effects
MH  - Brain Ischemia/metabolism/*physiopathology
MH  - Cerebrovascular Circulation/drug effects
MH  - Disease Models, Animal
MH  - Energy Metabolism/*drug effects
MH  - Motor Activity
MH  - Papaverine/pharmacology
MH  - Quinones/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Ubiquinone/analogs & derivatives
EDAT- 1989/05/01 00:00
MHDA- 1989/05/01 00:01
CRDT- 1989/05/01 00:00
PHST- 1988/08/02 00:00 [received]
PHST- 1989/01/04 00:00 [revised]
PHST- 1989/01/07 00:00 [accepted]
PHST- 1989/05/01 00:00 [pubmed]
PHST- 1989/05/01 00:01 [medline]
PHST- 1989/05/01 00:00 [entrez]
AID - 0167494389900022 [pii]
AID - 10.1016/0167-4943(89)90002-2 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 1989 May;8(3):193-202. doi: 10.1016/0167-4943(89)90002-2.