PMID- 27646598
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20181025
IS  - 1029-2330 (Electronic)
IS  - 1026-7158 (Linking)
VI  - 25
IP  - 3
DP  - 2017 Mar
TI  - Recent trends in targeted therapy of cancer using graphene oxide-modified 
      multifunctional nanomedicines.
PG  - 202-215
LID - 10.1080/1061186X.2016.1238475 [doi]
AB  - Rapid progresses in nanotechnology fields have led us to use a number of advanced 
      nanomaterials (NMs) for engineering smart multifunctional nanoparticles 
      (NPs)/nanosystems (NSs) for targeted diagnosis and therapy of various diseases 
      including different types of malignancies. For the effective therapy of any type 
      of solid tumor, the treatment modality should ideally solely target the aberrant 
      cancerous cells/tissue with no/trivial impacts on the healthy cells. One approach 
      to achieve such unprecedented impacts can be fulfilled through the use of 
      seamless multimodal NPs/NSs with photoacoustic properties that can be achieved 
      using advanced NMs such as graphene oxide (GO). It is considered as one of the 
      most promising materials that have been used in the development of various 
      NPs/NSs. GO-based targeted NSs can be engineered as programmable drug delivery 
      systems (DDSs) to perform on-demand chemotherapy combined with photonic energy 
      for photothermal therapy (PTT) or photodynamic therapy (PDT). In the current 
      review, we provide important insights on the GO-based NSs and discuss their 
      potentials for the photodynamic/photothermal ablation of cancer in combination 
      with anticancer agents.
FAU - Rahmanian, Nazanin
AU  - Rahmanian N
AD  - a Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy , Tabriz 
      University of Medical Sciences , Tabriz , Iran.
FAU - Eskandani, Morteza
AU  - Eskandani M
AD  - a Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy , Tabriz 
      University of Medical Sciences , Tabriz , Iran.
FAU - Barar, Jaleh
AU  - Barar J
AD  - a Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy , Tabriz 
      University of Medical Sciences , Tabriz , Iran.
FAU - Omidi, Yadollah
AU  - Omidi Y
AD  - a Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy , Tabriz 
      University of Medical Sciences , Tabriz , Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161006
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Graphite/*administration & dosage
MH  - Humans
MH  - Nanoparticles/chemistry/*therapeutic use
MH  - Neoplasms/therapy
OTO - NOTNLM
OT  - Graphene oxide
OT  - nanomedicine
OT  - photothermal therapy
OT  - targeted drug delivery
EDAT- 2016/09/21 06:00
MHDA- 2018/02/16 06:00
CRDT- 2016/09/21 06:00
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2016/09/21 06:00 [entrez]
AID - 10.1080/1061186X.2016.1238475 [doi]
PST - ppublish
SO  - J Drug Target. 2017 Mar;25(3):202-215. doi: 10.1080/1061186X.2016.1238475. Epub 
      2016 Oct 6.