PMID- 27646684
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Sep 20
TI  - Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and 
      Neonatal Rats.
PG  - 33430
LID - 10.1038/srep33430 [doi]
LID - 33430
AB  - Alteration of gut microbial colonization process may influence susceptibility of 
      the newborn/infant to infectious and chronic disease. Infectious disease risk 
      leads to widespread use of non-prescription antimicrobials in household products 
      such as Triclocarban (TCC), an antimicrobial compound in personal care products. 
      TCC concentrates in and is transferred through the milk to suckling offspring. 
      TCC exposure during gestation and lactation significantly reduced phylogenetic 
      diversity (PD) among exposed dams and neonates. Among dams using weighted UniFrac 
      distances, TCC induced significant dysbiosis of gut microbiota by gestational day 
      (GD) 18, a trend that continued after delivery. Similarly, an overall 
      restructuring of gut microbiota occurred in neonates. By postnatal day (PND) 12, 
      communities separated based on exposure status and became significantly different 
      at PND 16. The ability of TCC to drive microbial dysbiosis warrants future 
      investigation to evaluate the safety of non-prescription antimicrobial use, 
      including TCC, during critical exposure windows.
FAU - Kennedy, Rebekah C
AU  - Kennedy RC
AD  - Department of Public Health, The University of Tennessee, Knoxville, TN 37996, 
      USA.
AD  - Comparative and Experimental Medicine, The University of Tennessee, Knoxville, TN 
      37996, USA.
FAU - Fling, Russell R
AU  - Fling RR
AD  - Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, 
      USA.
FAU - Robeson, Michael S
AU  - Robeson MS
AD  - Department of Fish, Wildlife &Conservation Biology, Colorado State University, 
      Fort Collins, CO 80523, USA.
AD  - USDA APHIS, National Wildlife Research Center, Fort Collins, CO 80521, USA.
FAU - Saxton, Arnold M
AU  - Saxton AM
AD  - Department of Animal Science, The University of Tennessee, Knoxville, TN 37996, 
      USA.
FAU - Donnell, Robert L
AU  - Donnell RL
AD  - Department of Biomedical and Diagnostic Sciences, The University of Tennessee, 
      Knoxville, TN 37996, USA.
FAU - Darcy, John L
AU  - Darcy JL
AD  - Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, 
      CO 80309, USA.
FAU - Bemis, David A
AU  - Bemis DA
AD  - Department of Biomedical and Diagnostic Sciences, The University of Tennessee, 
      Knoxville, TN 37996, USA.
FAU - Liu, Jiang
AU  - Liu J
AD  - Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, 
      USA.
FAU - Zhao, Ling
AU  - Zhao L
AD  - Department of Nutrition, The University of Tennessee Knoxville, TN 37996, USA.
FAU - Chen, Jiangang
AU  - Chen J
AD  - Department of Public Health, The University of Tennessee, Knoxville, TN 37996, 
      USA.
LA  - eng
GR  - R21 ES017475/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160920
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Carbanilides)
RN  - BGG1Y1ED0Y (triclocarban)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Anti-Infective Agents, Local/*pharmacology
MH  - Biodiversity
MH  - Carbanilides/*pharmacology
MH  - Feces/microbiology
MH  - Female
MH  - *Gastrointestinal Microbiome
MH  - Gestational Age
MH  - Lactation
MH  - *Maternal Exposure
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
PMC - PMC5028839
EDAT- 2016/09/21 06:00
MHDA- 2018/06/07 06:00
PMCR- 2016/09/20
CRDT- 2016/09/21 06:00
PHST- 2016/02/18 00:00 [received]
PHST- 2016/08/12 00:00 [accepted]
PHST- 2016/09/21 06:00 [entrez]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2016/09/20 00:00 [pmc-release]
AID - srep33430 [pii]
AID - 10.1038/srep33430 [doi]
PST - epublish
SO  - Sci Rep. 2016 Sep 20;6:33430. doi: 10.1038/srep33430.