PMID- 27646959
OWN - NLM
STAT- MEDLINE
DCOM- 20171103
LR  - 20181113
IS  - 1863-2300 (Electronic)
IS  - 1863-2297 (Print)
IS  - 1863-2297 (Linking)
VI  - 39
IP  - 2
DP  - 2017 Feb
TI  - Tolerogenic dendritic cells.
PG  - 113-120
LID - 10.1007/s00281-016-0587-8 [doi]
AB  - Deficits in immunological tolerance against self-antigens and antigens provided 
      by the diet and commensal microbiota can result in the development of 
      inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal 
      regulators of the immune response, specialized in antigen presentation to drive T 
      cell priming and differentiation. DCs also have a tolerogenic function, 
      participating in the enforcement of central and peripheral tolerance and the 
      resolution of ongoing immune responses. Thus, DCs control effector and regulatory 
      mechanisms relevant to the pathology of autoimmune disorders. In this review, we 
      discuss recent findings regarding the control of the adaptive immune response by 
      tolerogenic DCs. A thorough understanding of the mechanisms that control the 
      tolerogenic DC phenotype will guide the development of novel strategies for the 
      treatment of autoimmunity.
FAU - Takenaka, Maisa C
AU  - Takenaka MC
AD  - Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard 
      Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.
FAU - Quintana, Francisco J
AU  - Quintana FJ
AUID- ORCID: 0000-0001-8156-0736
AD  - Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard 
      Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA. 
      fquintana@rics.bwh.harvard.edu.
AD  - Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. 
      fquintana@rics.bwh.harvard.edu.
LA  - eng
GR  - R01 AI093903/AI/NIAID NIH HHS/United States
GR  - R01 ES025530/ES/NIEHS NIH HHS/United States
GR  - R21 NS087867/NS/NINDS NIH HHS/United States
GR  - R56 AI093903/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160919
PL  - Germany
TA  - Semin Immunopathol
JT  - Seminars in immunopathology
JID - 101308769
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Receptors, Cholinergic)
RN  - 126465-35-8 (Perforin)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Autoimmunity
MH  - Biomarkers
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cytokines/metabolism
MH  - Dendritic Cells/cytology/*immunology/metabolism
MH  - Gene Expression
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Humans
MH  - *Immune Tolerance
MH  - Perforin/genetics
MH  - Receptors, Cholinergic/metabolism
MH  - T-Lymphocyte Subsets/immunology/metabolism
PMC - PMC5296314
MID - NIHMS817759
OTO - NOTNLM
OT  - AhR
OT  - Autoimmunity
OT  - Dendritic cell
OT  - Nanoparticles
OT  - Tolerance
EDAT- 2016/09/21 06:00
MHDA- 2017/11/04 06:00
PMCR- 2018/02/01
CRDT- 2016/09/21 06:00
PHST- 2016/06/30 00:00 [received]
PHST- 2016/08/22 00:00 [accepted]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/11/04 06:00 [medline]
PHST- 2016/09/21 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1007/s00281-016-0587-8 [pii]
AID - 10.1007/s00281-016-0587-8 [doi]
PST - ppublish
SO  - Semin Immunopathol. 2017 Feb;39(2):113-120. doi: 10.1007/s00281-016-0587-8. Epub 
      2016 Sep 19.