PMID- 27647626
OWN - NLM
STAT- MEDLINE
DCOM- 20171208
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 17
IP  - 4
DP  - 2017 Apr
TI  - Social and Financial Outcomes of Living Liver Donation: A Prospective 
      Investigation Within the Adult-to-Adult Living Donor Liver Transplantation Cohort 
      Study 2 (A2ALL-2).
PG  - 1081-1096
LID - 10.1111/ajt.14055 [doi]
AB  - Because results from single-center (mostly kidney) donor studies demonstrate 
      interpersonal relationship and financial strains for some donors, we conducted a 
      liver donor study involving nine centers within the Adult-to-Adult Living Donor 
      Liver Transplantation Cohort Study 2 (A2ALL-2) consortium. Among other 
      initiatives, A2ALL-2 examined the nature of these outcomes following donation. 
      Using validated measures, donors were prospectively surveyed before donation and 
      at 3, 6, 12, and 24 mo after donation. Repeated-measures regression models were 
      used to examine social relationship and financial outcomes over time and to 
      identify relevant predictors. Of 297 eligible donors, 271 (91%) consented and 
      were interviewed at least once. Relationship changes were positive overall across 
      postdonation time points, with nearly one-third reporting improved donor family 
      and spousal or partner relationships and >50% reporting improved recipient 
      relationships. The majority of donors, however, reported cumulative out-of-pocket 
      medical and nonmedical expenses, which were judged burdensome by 44% of donors. 
      Lower income predicted burdensome donation costs. Those who anticipated financial 
      concerns and who held nonprofessional positions before donation were more likely 
      to experience adverse financial outcomes. These data support the need for 
      initiatives to reduce financial burden.
CI  - (c) 2016 The American Society of Transplantation and the American Society of 
      Transplant Surgeons.
FAU - DiMartini, A
AU  - DiMartini A
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA.
AD  - Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
FAU - Dew, M A
AU  - Dew MA
AUID- ORCID: 0000-0002-4666-1870
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA.
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA.
AD  - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
AD  - Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA.
FAU - Liu, Q
AU  - Liu Q
AD  - Arbor Research Collaborative for Health, Ann Arbor, MI.
FAU - Simpson, M A
AU  - Simpson MA
AD  - Lahey Hospital and Medical Center Clinical Research and Education, Burlington, 
      MA.
AD  - Department of Transplantation, Lahey Hospital and Medical Center, Burlington, MA.
FAU - Ladner, D P
AU  - Ladner DP
AD  - Northwestern University Transplant Outcomes Research Collaborative (NUTORC), 
      Chicago, IL.
AD  - Comprehensive Transplant Center, Northwestern University, Chicago, IL.
FAU - Smith, A R
AU  - Smith AR
AD  - Arbor Research Collaborative for Health, Ann Arbor, MI.
AD  - Department of Biostatistics, University of Michigan, Ann Arbor, MI.
FAU - Zee, J
AU  - Zee J
AD  - Arbor Research Collaborative for Health, Ann Arbor, MI.
FAU - Abbey, S
AU  - Abbey S
AD  - Department of Psychiatry, University of Toronto and University Health Network, 
      Toronto, ON, Canada.
FAU - Gillespie, B W
AU  - Gillespie BW
AD  - Department of Biostatistics, University of Michigan, Ann Arbor, MI.
FAU - Weinrieb, R
AU  - Weinrieb R
AD  - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA.
FAU - Mandell, M S
AU  - Mandell MS
AD  - Department of Anesthesiology, University of Colorado, Denver, CO.
FAU - Fisher, R A
AU  - Fisher RA
AD  - Department of Transplant Surgery, Virginia Commonwealth University, Richmond, VA.
AD  - Beth Israel Deaconess Department of Surgery, Harvard University, Boston, MA.
FAU - Emond, J C
AU  - Emond JC
AD  - Department of Surgery, Columbia University Medical Center, New York, NY.
FAU - Freise, C E
AU  - Freise CE
AD  - Department of Surgery, University of California at San Francisco, San Francisco, 
      CA.
FAU - Sherker, A H
AU  - Sherker AH
AD  - Liver Diseases Research Branch, Division of Digestive Diseases and Nutrition, 
      National Institute of Diabetes and Digestive and Kidney Diseases, National 
      Institutes of Health, Bethesda, MD.
FAU - Butt, Z
AU  - Butt Z
AD  - Northwestern University Transplant Outcomes Research Collaborative (NUTORC), 
      Chicago, IL.
AD  - Comprehensive Transplant Center, Northwestern University, Chicago, IL.
AD  - Department of Medical Social Sciences, Northwestern University Feinberg School of 
      Medicine, Chicago, IL.
AD  - Institute for Public Health and Medicine, Northwestern University Feinberg School 
      of Medicine, Chicago, IL.
LA  - eng
GR  - U01 DK062536/DK/NIDDK NIH HHS/United States
GR  - U01 DK062531/DK/NIDDK NIH HHS/United States
GR  - U01 DK062498/DK/NIDDK NIH HHS/United States
GR  - U01 DK062444/DK/NIDDK NIH HHS/United States
GR  - U01 DK085515/DK/NIDDK NIH HHS/United States
GR  - U01 DK062494/DK/NIDDK NIH HHS/United States
GR  - U01 DK062483/DK/NIDDK NIH HHS/United States
GR  - U01 DK062467/DK/NIDDK NIH HHS/United States
GR  - U01 DK085587/DK/NIDDK NIH HHS/United States
GR  - U01 DK085563/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20161110
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - *Liver Transplantation
MH  - Living Donors/*psychology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Quality of Life
MH  - Social Support
MH  - *Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Tissue and Organ Procurement/*economics
PMC - PMC5359081
MID - NIHMS818467
OTO - NOTNLM
OT  - basic (laboratory) research/science
OT  - donors and donation: donor follow-up
OT  - donors and donation: living
OT  - income
OT  - liver transplantation/hepatology
OT  - liver transplantation: living donor
EDAT- 2016/09/21 06:00
MHDA- 2017/12/09 06:00
PMCR- 2018/04/01
CRDT- 2016/09/21 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/08/04 00:00 [revised]
PHST- 2016/09/07 00:00 [accepted]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/12/09 06:00 [medline]
PHST- 2016/09/21 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - S1600-6135(22)24947-8 [pii]
AID - 10.1111/ajt.14055 [doi]
PST - ppublish
SO  - Am J Transplant. 2017 Apr;17(4):1081-1096. doi: 10.1111/ajt.14055. Epub 2016 Nov 
      10.