PMID- 27647708
OWN - NLM
STAT- MEDLINE
DCOM- 20170816
LR  - 20170816
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 95
IP  - 3
DP  - 2017 May
TI  - Surgical outcomes of lamellar macular holes with and without lamellar 
      hole-associated epiretinal proliferation.
PG  - e221-e226
LID - 10.1111/aos.13245 [doi]
AB  - PURPOSE: To report the clinical findings and surgical outcomes of lamellar 
      macular holes (LMHs) with and without lamellar hole-associated epiretinal 
      proliferation (LHEP). METHODS: A retrospective review was performed of 73 eyes of 
      73 patients who underwent vitrectomy for LMH. Patients were grouped according to 
      the presence of LHEP on preoperative spectral-domain optical coherence tomography 
      (SD-OCT). Postoperative best-corrected visual acuity (BCVA) and OCT features were 
      compared between LMH patients with and without LHEP. RESULTS: Lamellar 
      hole-associated epiretinal proliferation (LHEP) was found in 15 of 73 eyes with 
      LMHs (20.5%). The mean age was 65.0 years. The mean follow-up duration was 
      21.5 months. Preoperatively, eyes with LHEP were characterized by a greater hole 
      diameter (p = 0.007), thinner fovea (p = 0.002) and greater incidence of outer 
      retinal disruption (p < 0.001). Best-corrected visual acuity (BCVA) significantly 
      improved after surgery in eyes without LHEP (p < 0.001), but showed no change in 
      eyes with LHEP (p = 0.185). Initial BCVA was not different between the two 
      groups; however, final BCVA was better in eyes without LHEP (logarithm of the 
      minimum angle of resolution (logMAR) BCVA, 0.10 +/- 0.10 versus 0.33 +/- 0.40, 
      p = 0.003). OCT evaluations of postoperative foveal configurations showed no 
      difference between the two groups (p = 0.171). No case developed a full-thickness 
      macular hole after surgery. CONCLUSION: There was no visual benefit after surgery 
      in LMH patients with LHEP. Different surgical indications for LMHs may be 
      warranted based on the presence of LHEP-associated pathology.
CI  - (c) 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Ko, Jaesang
AU  - Ko J
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
AD  - Changnyeong-gun Public Health Center, Changnyeong, Gyeongnam, Korea.
FAU - Kim, Gyu Ah
AU  - Kim GA
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lee, Sung Chul
AU  - Lee SC
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lee, Jihwan
AU  - Lee J
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Koh, Hyoung Jun
AU  - Koh HJ
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Kim, Sung Soo
AU  - Kim SS
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Byeon, Suk Ho
AU  - Byeon SH
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lee, Christopher Seungkyu
AU  - Lee CS
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160920
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Aged
MH  - Epiretinal Membrane/diagnosis/*etiology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Perforations/complications/diagnosis/*surgery
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Treatment Outcome
MH  - *Visual Acuity
MH  - Vitrectomy/*methods
OTO - NOTNLM
OT  - epiretinal membrane
OT  - epiretinal proliferation
OT  - lamellar hole-associated epiretinal proliferation
OT  - lamellar macular hole
OT  - vitrectomy
EDAT- 2016/09/21 06:00
MHDA- 2017/08/17 06:00
CRDT- 2016/09/21 06:00
PHST- 2016/02/10 00:00 [received]
PHST- 2016/07/25 00:00 [accepted]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/08/17 06:00 [medline]
PHST- 2016/09/21 06:00 [entrez]
AID - 10.1111/aos.13245 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2017 May;95(3):e221-e226. doi: 10.1111/aos.13245. Epub 2016 Sep 
      20.