PMID- 27647823
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20191210
IS  - 1616-5195 (Electronic)
IS  - 1616-5187 (Linking)
VI  - 17
IP  - 2
DP  - 2017 Feb
TI  - Chlorhexidine Loaded Cyclodextrin Containing PMMA Nanogels as Antimicrobial 
      Coating and Delivery Systems.
LID - 10.1002/mabi.201600230 [doi]
AB  - Antimicrobial nanogels, aggregates, and films are prepared by complexation of the 
      antiseptic and bacteriostatic agent chlorhexidine (CHX) for medical and dental 
      applications. A series of alpha-, beta-, and gamma-cyclodextrin methacrylate (CD-MA) 
      containing hydrophobic poly(methyl methacrylate) (PMMA) based nanogels are loaded 
      quantitatively with CHX in aqueous dispersion. The results show that CHX is 
      enhancedly complexed by the use of CD-MA domains in the particles structure. 
      beta-CD-MA nanogels present the highest uptake of CHX. Furthermore, it is observed 
      that the uptake of CHX in nanogels is influenced by the hydrophobic PMMA 
      structure. CHX acts as external cross-linker of nanogels by formation of 1:2 
      (CHX:CD-MA) inclusion complexes of two beta-CD-MA units on the surfaces of two 
      different nanogels. The nanogels adsorb easily onto glass surfaces by physical 
      self-bonding and formation of a dense crosslinked nanogel film. Biological tests 
      of the applied CHX nanogels with regard to antimicrobial efficiency are 
      successfully performed against Staphylococcus aureus.
CI  - (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Kettel, Markus J
AU  - Kettel MJ
AD  - DWI - Leibniz Institute for Interactive Materials e. V. and Textile and 
      Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstrasse 50, 52056, 
      Aachen, Germany.
FAU - Heine, Elisabeth
AU  - Heine E
AD  - DWI - Leibniz Institute for Interactive Materials e. V. and Textile and 
      Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstrasse 50, 52056, 
      Aachen, Germany.
FAU - Schaefer, Karola
AU  - Schaefer K
AD  - DWI - Leibniz Institute for Interactive Materials e. V. and Textile and 
      Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstrasse 50, 52056, 
      Aachen, Germany.
FAU - Moeller, Martin
AU  - Moeller M
AD  - DWI - Leibniz Institute for Interactive Materials e. V. and Textile and 
      Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstrasse 50, 52056, 
      Aachen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160920
PL  - Germany
TA  - Macromol Biosci
JT  - Macromolecular bioscience
JID - 101135941
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Nanogels)
RN  - 0 (gamma-Cyclodextrins)
RN  - 0 (polyethylene glycol polyethyleneimine nanogel)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 9002-98-6 (Polyethyleneimine)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - KZJ0BYZ5VA (gamma-cyclodextrin)
RN  - R4KO0DY52L (Chlorhexidine)
SB  - IM
MH  - Anti-Infective Agents/*pharmacology
MH  - Chlorhexidine/*pharmacology
MH  - Coated Materials, Biocompatible/*pharmacology
MH  - Cross-Linking Reagents/chemistry
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Microbial Sensitivity Tests
MH  - Nanogels
MH  - Polyethylene Glycols/*chemistry
MH  - Polyethyleneimine/*chemistry
MH  - Polymethyl Methacrylate/*chemistry
MH  - Spectrophotometry, Ultraviolet
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Staphylococcus aureus/drug effects/growth & development
MH  - Surface Properties
MH  - gamma-Cyclodextrins/*chemistry
OTO - NOTNLM
OT  - Chlorhexidine
OT  - PMMA nanogels
OT  - cyclodextrin
OT  - drug delivery systems
OT  - nanocontainers
EDAT- 2016/09/21 06:00
MHDA- 2017/10/14 06:00
CRDT- 2016/09/21 06:00
PHST- 2016/06/05 00:00 [received]
PHST- 2016/07/29 00:00 [revised]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2016/09/21 06:00 [entrez]
AID - 10.1002/mabi.201600230 [doi]
PST - ppublish
SO  - Macromol Biosci. 2017 Feb;17(2). doi: 10.1002/mabi.201600230. Epub 2016 Sep 20.